Gene
arhgap33
- ID
- ZDB-GENE-121105-12
- Name
- Rho GTPase activating protein 33
- Symbol
- arhgap33 Nomenclature History
- Previous Names
-
- SNX26 (1)
- wu:fc76f02
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be active in several cellular components, including Golgi apparatus; actin cytoskeleton; and nuclear lumen. Orthologous to human ARHGAP33 (Rho GTPase activating protein 33).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Xie et al., 2024
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa9276 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa12075 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa17463 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa19149 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa19150 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa36244 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa36245 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa36246 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa42808 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | PX Domain-Containing Rho GAP | PX domain superfamily | Rho GTPase-activating protein domain | Rho GTPase activation protein | SH3 domain | SH3-like domain superfamily |
---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2B5A9 | InterPro | 1907 | ||||||
UniProtKB:A0A8M2B4S4 | InterPro | 1890 | ||||||
UniProtKB:A0A8M2B4T5 | InterPro | 1839 | ||||||
UniProtKB:A0A8N7UW30 | InterPro | 612 | ||||||
UniProtKB:A0A8M2B593 | InterPro | 1895 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
arhgap33-201
(1)
|
Ensembl | 797 nt | ||
mRNA |
arhgap33-202
(1)
|
Ensembl | 1,861 nt | ||
mRNA |
arhgap33-203
(1)
|
Ensembl | 3,519 nt | ||
mRNA |
arhgap33-205
(1)
|
Ensembl | 3,336 nt | ||
ncRNA |
arhgap33-002
(1)
|
Ensembl | 612 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-77D17 | ZFIN Curated Data | |
Encodes | EST | fc76f02 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_068214241 (1) | 8509 nt | ||
Genomic | GenBank:AL844567 (1) | 174845 nt | ||
Polypeptide | UniProtKB:A0AB32TA93 (1) | 1917 aa |
- Comparative Orthology
- Alliance
Species | Symbol | Chromosome | Accession # | Evidence |
---|---|---|---|---|
Human | ARHGAP33 | 19 | Amino acid sequence comparison (1) |
- Xie, B., Liang, J., Jiang, J., Zeng, T., Liu, L., Xie, D., Zhu, G., Xiong, L., Zhang, K., Liu, D., Gong, J., Chen, X., Lai, R., Xie, H. (2024) Zebrafish myo7aa affects congenital hearing by regulating Rho-GTPase signaling. Frontiers in molecular neuroscience. 17:14051091405109
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Xu, L., Yin, W., Xia, J., Peng, M., Li, S., Lin, S., Pei, A., and Shum, X. (2012) An anti-apoptotic role of SNX7 is required for liver development in zebrafish. Hepatology (Baltimore, Md.). 55(6):1985-1993
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