ZFIN is now using GRCz12tu for Genomic Data
Gene
tapbpl
- ID
- ZDB-GENE-121003-1
- Name
- TAP binding protein like
- Symbol
- tapbpl Nomenclature History
- Previous Names
-
- tapbpr (1)
- fk53d08
- wu:fk53d08
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable MHC class I protein complex binding activity and TAP complex binding activity. Predicted to be involved in peptide antigen assembly with MHC class I protein complex. Predicted to be located in plasma membrane. Predicted to be part of MHC class I peptide loading complex. Orthologous to human TAPBPL (TAP binding protein like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Gao et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Immune Recognition and Response Modulators | Immunoglobulin C1-set | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin V-set domain | Tapasin |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1QHB2 | InterPro | 462 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tapbpl-201
(1)
|
Ensembl | 963 nt | ||
| mRNA |
tapbpl-202
(1)
|
Ensembl | 4,755 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-234A4 | ||
| Contained in | BAC | CH211-254C9 | ||
| Encodes | EST | fk53d08 |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001919950 (1) | GRCz12tu | 1771 nt | |
| Genomic | GenBank:CU104697 (1) | 181691 nt | ||
| Polypeptide | UniProtKB:A0A8M1QHB2 (1) | 462 aa |
- Comparative Orthology
- Alliance
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | TAPBPL | 12 | Phylogenetic tree (1) |
- Grimholt, U. (2018) Whole genome duplications have provided teleosts with many roads to peptide loaded MHC class I molecules. BMC Evolutionary Biology. 18:25
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gao, Y., Wu, H., Wang, Q., Qu, J., Liu, Q., Xiao, J., Zhang, Y. (2014) A live attenuated combination vaccine evokes effective immune-mediated protection against Edwardsiella tarda and Vibrio anguillarum. Vaccine. 32(45):5937-44
- Yang, D., Liu, Q., Ni, C., Li, S., Wu, H., Wang, Q., Xiao, J., and Zhang, Y. (2013) Gene expression profiling in live attenuated Edwardsiella tarda vaccine immunized and challenged zebrafish: Insights into the basic mechanisms of protection seen in immunized fish. Developmental and comparative immunology. 40(2):132-41
- Yang, D., Liu, Q., Yang, M., Wu, H., Wang, Q., Xiao, J., and Zhang, Y. (2012) RNA-seq liver transcriptome analysis reveals an activated MHC-I pathway and an inhibited MHC-II pathway at the early stage of vaccine immunization in zebrafish. BMC Genomics. 13(1):319
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