Gene
micu3b
- ID
- ZDB-GENE-120813-5
- Name
- mitochondrial calcium uptake family, member 3b
- Symbol
- micu3b Nomenclature History
- Previous Names
-
- efha2b
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Predicted to be involved in calcium import into the mitochondrion and mitochondrial calcium ion homeostasis. Predicted to act upstream of or within mitochondrial calcium ion transmembrane transport. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be part of uniplex complex. Orthologous to human MICU3 (mitochondrial calcium uptake family member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Calcium uptake protein 1/2/3 | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q593 | InterPro | 353 | ||||
| UniProtKB:A0A8M9Q1H9 | InterPro | 321 | ||||
| UniProtKB:A0A2R8Q0S1 | InterPro | 470 | ||||
| UniProtKB:A0A8M9QPH0 | InterPro | 367 | ||||
| UniProtKB:E7FF65 | InterPro | 484 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
micu3b-201
(1)
|
Ensembl | 4,964 nt | ||
| mRNA |
micu3b-202
(1)
|
Ensembl | 263 nt | ||
| mRNA |
micu3b-203
(1)
|
Ensembl | 3,823 nt | ||
| mRNA |
micu3b-204
(1)
|
Ensembl | 305 nt | ||
| mRNA |
micu3b-205
(1)
|
Ensembl | 4,922 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-56I11 | ZFIN Curated Data | |
| Contained in | BAC | CH211-186K13 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009291166 (1) | 3904 nt | ||
| Genomic | RefSeq:NW_018394914 (1) | 419062 nt | ||
| Polypeptide | UniProtKB:E7FF65 (1) | 484 aa |
- Comparative Orthology
- Alliance
- Hutto, R.A., Bisbach, C.M., Abbas, F., Brock, D.C., Cleghorn, W.M., Parker, E.D., Bauer, B.H., Ge, W., Vinberg, F., Hurley, J.B., Brockerhoff, S.E. (2019) Increasing Ca2+ in photoreceptor mitochondria alters metabolites, accelerates photoresponse recovery, and reveals adaptations to mitochondrial stress. Cell death and differentiation. 27(3):1067-1085
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Ma, A.C., McNulty, M.S., Tanya, P.L., Jarryd, C.M., Martínez-Gálvez, G., Argue, D.P., Lee, H.B., Urban, M.D., Bullard, C.E., Blackburn, P.R., Man, T.K., Clark, K.J., Ekker, S.C. (2016) FusX: A rapid one-step TALE assembly system for genome science. Human gene therapy. 27(6):451-63
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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