ZFIN is now using GRCz12tu for Genomic Data
Gene
mgmt
- ID
- ZDB-GENE-120614-1
- Name
- O-6-methylguanine-DNA methyltransferase
- Symbol
- mgmt Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable methylated-DNA-[protein]-cysteine S-methyltransferase activity. Predicted to be involved in DNA repair. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland cancer (multiple); granulosa cell tumor; high grade glioma (multiple); and retinoblastoma. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR001497 | Methylated-DNA-[protein]-cysteine S-methyltransferase, active site |
| Conserved_site | IPR018350 | Transcription factor COE, conserved site |
| Domain | IPR002909 | IPT domain |
| Domain | IPR008332 | Methylguanine DNA methyltransferase, ribonuclease-like domain |
| Domain | IPR014048 | Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding |
| Domain | IPR032200 | Transcription factor COE, DNA-binding domain |
| Domain | IPR032201 | Transcription factor COE, helix-loop-helix domain |
| Domain | IPR038006 | Transcription factor COE, IPT domain |
| Family | IPR003523 | Transcription factor COE |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
| Homologous_superfamily | IPR036217 | Methylated DNA-protein cysteine methyltransferase, DNA binding domain |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036631 | Methylated DNA-protein cysteine methyltransferase domain superfamily |
| Homologous_superfamily | IPR038173 | Transcription factor COE, DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | Methylated DNA-protein cysteine methyltransferase, DNA binding domain | Methylated DNA-protein cysteine methyltransferase domain superfamily | Methylated-DNA-[protein]-cysteine S-methyltransferase, active site | Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding | Methylguanine DNA methyltransferase, ribonuclease-like domain | Transcription factor COE | Transcription factor COE, conserved site | Transcription factor COE, DNA-binding domain | Transcription factor COE, DNA-binding domain superfamily | Transcription factor COE, helix-loop-helix domain | Transcription factor COE, IPT domain | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:X1WB89 | InterPro | 187 | |||||||||||||||
| UniProtKB:F1R3V2 | InterPro | 192 | |||||||||||||||
| UniProtKB:A0AC58HN10 | InterPro | 561 | |||||||||||||||
| UniProtKB:A0AC58HN15 | InterPro | 435 | |||||||||||||||
| UniProtKB:A0AC58HN16 | InterPro | 430 | |||||||||||||||
| UniProtKB:A0AC58HN17 | InterPro | 514 | |||||||||||||||
| UniProtKB:A0AC58HN19 | InterPro | 566 | |||||||||||||||
| UniProtKB:A0AC58HN21 | InterPro | 566 | |||||||||||||||
| UniProtKB:A0AC58HN28 | InterPro | 383 | |||||||||||||||
| UniProtKB:A0ACD6B716 | InterPro | 514 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers