ZFIN is now using GRCz12tu for Genomic Data
Gene
il21
- ID
- ZDB-GENE-120510-4
- Name
- interleukin 21
- Symbol
- il21 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cytokine activity. Predicted to be involved in positive regulation of cytokine production and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in extracellular space. Is expressed in several structures, including gill; heart; immune system; liver; and muscle. Human ortholog(s) of this gene implicated in asthma; common variable immunodeficiency 11; hepatocellular carcinoma; and systemic lupus erythematosus. Orthologous to human IL21 (interleukin 21).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa35618 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-il21 | N/A | Lawir et al., 2019 |
| MO2-il21 | N/A | Lawir et al., 2019 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| common variable immunodeficiency 11 | Alliance | ?Immunodeficiency, common variable, 11 | 615767 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Four-helical cytokine-like, core | Interleukin-15/Interleukin-21 family |
|---|---|---|---|---|
| UniProtKB:A1YYP5 | InterPro | 151 | ||
| UniProtKB:A0A8M2BKC7 | InterPro | 144 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
No data available
- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128574 (1) | 1237 nt | ||
| Genomic | GenBank:LO017950 (1) | 40870 nt | ||
| Polypeptide | UniProtKB:A1YYP5 (1) | 151 aa |
- Tesoriere, A., Ghirardo, R., Terrin, F., Sernesi, F., Meneghetti, G., Dalla Valle, L., Dinarello, A., Argenton, F. (2025) Tail Fin Regeneration in Zebrafish: The Role of Non-canonical Crosstalk Between STAT3 and Vitamin D Pathway. International journal of biological sciences. 21:271284271-284
- Guo, D., Xiong, H., Yang, Z., Zhang, R., Shi, P., Yao, Y., Liu, M., Xu, C., Wang, Q.K. (2024) Lysosomal membrane protein TMEM106B modulates hematopoietic stem and progenitor cell proliferation and differentiation by regulating LAMP2A stability. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 38:e23870e23870
- Sobah, M.L., Liongue, C., Ward, A.C. (2024) Stat3 regulates developmental hematopoiesis and impacts myeloid cell function via canonical and non-canonical modalities. Journal of Innate Immunity. 16(1):262-282
- Karagöz, A., Beler, M., Altun, B.D., Ünal, İ., Cansız, D., Gündüz, H., Alturfan, A.A., Emekli-Alturfan, E., Erçalık-Yalçınkaya, Ş. (2023) Panoramic Dental X-ray Exposure Leads to Oxidative stress, Inflammation and Apoptosis-mediated Developmental Defects in Zebrafish Embryos. Journal of stomatology, oral and maxillofacial surgery. 124(6S):101661
- Sobah, M.L., Scott, A.C., Laird, M., Koole, C., Liongue, C., Ward, A.C. (2023) Socs3b regulates the development and function of innate immune cells in zebrafish. Frontiers in immunology. 14:11197271119727
- Dandin, E., Üstündağ, Ü.V., Ünal, İ., Ateş-Kalkan, P.S., Cansız, D., Beler, M., Ak, E., Alturfan, A.A., Emekli-Alturfan, E. (2022) Stevioside ameliorates hyperglycemia and glucose intolerance, in a diet-induced obese zebrafish model, through epigenetic, oxidative stress and inflammatory regulation. Obesity research & clinical practice. 16(1):23-29
- Hui, S.P., Sugimoto, K., Sheng, D.Z., Kikuchi, K. (2022) Regulatory T cells regulate blastemal proliferation during zebrafish caudal fin regeneration. Frontiers in immunology. 13:981000
- Gong, Q.Y., Yang, M.J., Yang, L.F., Chen, Z.G., Jiang, M., Peng, B. (2020) Metabolic modulation of redox state confounds fish survival against Vibrio alginolyticus infection. Microbial biotechnology. 13:796-812
- Jiang, M., Yang, L., Chen, Z.G., Lai, S.S., Zheng, J., Peng, B. (2020) Exogenous maltose enhances Zebrafish immunity to levofloxacin-resistant Vibrio alginolyticus. Microbial biotechnology. 13(4):1213-1227
- Lawir, D.F., Hess, I., Sikora, K., Iwanami, N., Siamishi, I., Schorpp, M., Boehm, T. (2019) Evolutionary transition from degenerate to nonredundant cytokine signaling networks supporting intrathymic T cell development. Proceedings of the National Academy of Sciences of the United States of America. 116(52):26759-26767
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