ZFIN is now using GRCz12tu for Genomic Data
Gene
ifit12
- ID
- ZDB-GENE-120406-2
- Name
- interferon-induced protein with tetratricopeptide repeats 12
- Symbol
- ifit12 Nomenclature History
- Previous Names
-
- Ifit12e (2)
- ifit5
- si:dkey-26g8.8
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to be involved in defense response to virus. Predicted to be active in cytosol. Is expressed in several structures, including caudal fin; gill; liver; muscle; and pleuroperitoneal region. Orthologous to several human genes including IFIT5 (interferon induced protein with tetratricopeptide repeats 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa15526 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22069 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22070 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42002 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 4 of 4
Show
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat |
|---|---|---|---|---|
| UniProtKB:A0A8M1NUT8 | InterPro | 474 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ifit12-201
(1)
|
Ensembl | 1,440 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001190465 (1) | 1450 nt | ||
| Genomic | GenBank:BX000534 (2) | 199670 nt | ||
| Polypeptide | UniProtKB:A0A8M1NUT8 (1) | 474 aa |
- Boskovic, S., Marín-Juez, R., Jasnic, J., Reischauer, S., El Sammak, H., Kojic, A., Faulkner, G., Radojkovic, D., Stainier, D.Y.R., Kojic, S. (2018) Characterization of zebrafish (Danio rerio) muscle ankyrin repeat proteins reveals their conserved response to endurance exercise. PLoS One. 13:e0204312
- Kavaliauskis, A., Arnemo, M., Speth, M.T., Lagos, L., Rishovd, A.L., Estepa, A., Griffiths, G., Gjøen, T. (2016) Protective effect of a recombinant VHSV-G vaccine using poly(I:C) loaded nanoparticles as an adjuvant in zebrafish (Danio rerio) infection model. Developmental and comparative immunology. 61:248-57
- Kavaliauskis, A., Arnemo, M., Kim, S.H., Ulanova, L., Speth, M., Novoa, B., Dios, S., Evensen, Ø., Griffiths, G.W., Gjøen, T. (2015) Use of Poly(I:C) Stabilized with Chitosan As a Vaccine-Adjuvant Against Viral Hemorrhagic Septicemia Virus Infection in Zebrafish. Zebrafish. 12(6):421-31
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
- Varela, M., Diaz-Rosales, P., Pereiro, P., Forn-Cuní, G., Costa, M.M., Dios, S., Romero, A., Figueras, A., Novoa, B. (2014) Interferon-Induced Genes of the Expanded IFIT Family Show Conserved Antiviral Activities in Non-Mammalian Species. PLoS One. 9:e100015
- Liu, Y., Zhang, Y.B., Liu, T.K., and Gui, J.F. (2013) Lineage-Specific Expansion of IFIT Gene Family: An Insight into Coevolution with IFN Gene Family. PLoS One. 8(6):e66859
- Gomez, G., Lee, J.H., Veldman, M.B., Lu, J., Xiao, X., and Lin, S. (2012) Identification of Vascular and Hematopoietic Genes Downstream of etsrp by Deep Sequencing in Zebrafish. PLoS One. 7(3):e31658
1 - 7 of 7
Show