ZFIN is now using GRCz12tu for Genomic Data
Gene
thbs1a
- ID
- ZDB-GENE-120402-2
- Name
- thrombospondin 1a
- Symbol
- thbs1a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Ambiguous Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable calcium ion binding activity. Predicted to be involved in negative regulation of angiogenesis. Predicted to be active in extracellular matrix. Is expressed in atrioventricular canal and bulbus arteriosus. Human ortholog(s) of this gene implicated in cholangiocarcinoma; pancreatic cancer; pancreatic ductal carcinoma; and primary open angle glaucoma. Orthologous to human THBS1 (thrombospondin 1).
- Genome Resources
-
- Alliance (1)
- Gene:100332237 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Complement Clr-like EGF domain | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like calcium-binding domain | EGF-like domain | Thrombospondin, C-terminal | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily | Thrombospondin, type 3-like repeat | Thrombospondin, type 3 repeat | TSP type-3 repeat | VWFC domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1RI72 | InterPro | 965 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
No data available
- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_073927957 (1) | GRCz12tu | 4931 nt | |
| Genomic | GenBank:JBMGRA010000017 (1) | |||
| Polypeptide | UniProtKB:A0A8M1RI72 (2) | 965 aa |
- Comparative Orthology
- Alliance
- Guo, J., Lin, K., Wang, S., He, X., Huang, Z., Zheng, M. (2024) Effects and mechanisms of Porphyromonas gingivalis outer membrane vesicles induced cardiovascular injury. BMC oral health. 24:112112
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2024) Transcriptome alterations in sf3b4-depleted zebrafish: Insights into cataract formation in retinitis pigmentosa model. Experimental Eye Research. 240:109819
- Kolb, J., Tsata, V., John, N., Kim, K., Möckel, C., Rosso, G., Kurbel, V., Parmar, A., Sharma, G., Karandasheva, K., Abuhattum, S., Lyraki, O., Beck, T., Müller, P., Schlüßler, R., Frischknecht, R., Wehner, A., Krombholz, N., Steigenberger, B., Beis, D., Takeoka, A., Blümcke, I., Möllmert, S., Singh, K., Guck, J., Kobow, K., Wehner, D. (2023) Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment. Nature communications. 14:68146814
- Abrial, M., Basu, S., Huang, M., Butty, V., Schwertner, A., Jeffrey, S., Jordan, D., Burns, C.E., Burns, C.G. (2022) Latent TGFβ binding proteins 1 and 3 protect the larval zebrafish outflow tract from aneurysmal dilatation. Disease models & mechanisms. 15(3):
- Forte-Gomez, H.F., Gioia, R., Tonelli, F., Kobbe, B., Koch, P., Bloch, W., Paulsson, M., Zaucke, F., Forlino, A., Wagener, R. (2022) Structure, evolution and expression of zebrafish cartilage oligomeric matrix protein (COMP, TSP5). CRISPR-Cas mutants show a dominant phenotype in myosepta. Frontiers in endocrinology. 13:10006621000662
- Asnani, A., Zheng, B., Liu, Y., Wang, Y., Chen, H.H., Vohra, A., Chi, A., Cornella-Taracido, I., Wang, H., Johns, D.G., Sosnovik, D.E., Peterson, R.T. (2018) Highly potent visnagin derivatives inhibit Cyp1 and prevent doxorubicin cardiotoxicity. JCI insight. 3(1)
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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