Gene
chd5
- ID
- ZDB-GENE-120314-2
- Name
- chromodomain helicase DNA binding protein 5
- Symbol
- chd5 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including ATP hydrolysis activity; ATP-dependent chromatin remodeler activity; and histone binding activity. Acts upstream of or within chromatin remodeling; embryonic viscerocranium morphogenesis; and head development. Predicted to be part of NuRD complex. Predicted to be active in chromatin and nucleus. Is expressed in brain; eye; and testis. Orthologous to human CHD5 (chromodomain helicase DNA binding protein 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Bishop et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Bishop et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-chd5 | N/A | Huang et al., 2013 |
| MO2-chd5 | N/A | Bishop et al., 2015 |
| MO3-chd5 | N/A | Bishop et al., 2015 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Parenti-Mignot neurodevelopmental syndrome | 619873 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR002464 | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site |
| Conserved_site | IPR019786 | Zinc finger, PHD-type, conserved site |
| Domain | IPR000330 | SNF2, N-terminal |
| Domain | IPR000953 | Chromo/chromo shadow domain |
| Domain | IPR001650 | Helicase, C-terminal domain-like |
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Domain Details Per Protein
| Protein | Additional Resources | Length | CHD, C-terminal 2 | CHD, N-terminal | CHD subfamily II, SANT-like domain | Chromo/chromo shadow domain | Chromo domain | Chromo-like domain superfamily | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site | Domain of unknown function DUF1087 | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase | SNF2-like, N-terminal domain superfamily | SNF2, N-terminal | SNF2/RAD5-like, C-terminal helicase domain | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AXS2 | InterPro | 2024 | |||||||||||||||||||
| UniProtKB:A0A8M1RSV6 | InterPro | 1996 | |||||||||||||||||||
| UniProtKB:A0A8M9QI56 | InterPro | 1995 | |||||||||||||||||||
| UniProtKB:A0A8M3BDR6 | InterPro | 2008 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-199M8 | ZFIN Curated Data | |
| Contained in | BAC | CH211-218G23 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-196G21 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009306105 (1) | 9519 nt | ||
| Genomic | GenBank:BX548000 (2) | 216767 nt | ||
| Polypeptide | UniProtKB:A0A8M3AXS2 (1) | 2024 aa |
- Kuretani, A., Yamamoto, T., Taira, M., Michiue, T. (2021) Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs. BMC ecology and evolution. 21:147
- Bishop, B., Ho, K.K., Tyler, K., Smith, A., Bonilla, S., Leung, Y.F., Ogas, J. (2015) The chromatin remodeler chd5 is necessary for proper head development during embryogenesis of Danio rerio. Biochimica et biophysica acta. Gene regulatory mechanisms. 1849(8):1040-50
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Lagman, D., Sundström, G., Daza, D.O., Abalo, X.M., and Larhammar, D. (2012) Expansion of transducin subunit gene families in early vertebrate tetraploidizations. Genomics. 100(4):203-211
- Zhu, C., Smith, T., McNulty, J., Rayla, A.L., Lakshmanan, A., Siekmann, A.F., Buffardi, M., Meng, X., Shin, J., Padmanabhan, A., Cifuentes, D., Giraldez, A.J., Look, A.T., Epstein, J.A., Lawson, N.D., and Wolfe, S.A. (2011) Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish. Development (Cambridge, England). 138(20):4555-4564
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