Gene
kcnj5
- ID
- ZDB-GENE-120215-97
- Name
- potassium inwardly rectifying channel subfamily J member 5
- Symbol
- kcnj5 Nomenclature History
- Previous Names
-
- si:ch73-13p12.1
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of monoatomic ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in brain; heart; myotome; pectoral fin; and pharyngeal arch. Human ortholog(s) of this gene implicated in atrial fibrillation; long QT syndrome 13; and primary hyperaldosteronism. Orthologous to human KCNJ5 (potassium inwardly rectifying channel subfamily J member 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| long QT syndrome 13 | Alliance | Long QT syndrome 13 | 613485 |
| primary hyperaldosteronism | Alliance | Hyperaldosteronism, familial, type III | 613677 |
1 - 2 of 2
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR040445 | Potassium channel, inwardly rectifying, transmembrane domain |
| Domain | IPR041647 | Inward rectifier potassium channel, C-terminal |
| Family | IPR016449 | Potassium channel, inwardly rectifying, Kir |
| Homologous_superfamily | IPR013518 | Potassium channel, inwardly rectifying, Kir, cytoplasmic |
| Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
1 - 5 of 5
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin E-set | Inward rectifier potassium channel, C-terminal | Potassium channel, inwardly rectifying, Kir | Potassium channel, inwardly rectifying, Kir, cytoplasmic | Potassium channel, inwardly rectifying, transmembrane domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IAD0 | InterPro | 425 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-13P12 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_695527 (1) | 1855 nt | ||
| Genomic | GenBank:FP236321 (1) | 88314 nt | ||
| Polypeptide | UniProtKB:A0A0R4IAD0 (1) | 425 aa |
- Silic, M.R., Murata, S.H., Park, S.J., Zhang, G. (2021) Evolution of inwardly rectifying potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(4):687-713
- Langenbacher, A.D., Shimizu, H., Hsu, W., Zhao, Y., Borges, A., Koehler, C., Chen, J.N. (2020) Mitochondrial Calcium Uniporter Deficiency in Zebrafish Causes Cardiomyopathy With Arrhythmia. Frontiers in Physiology. 11:617492
- Yamada, N., Asano, Y., Fujita, M., Yamazaki, S., Inanobe, A., Matsuura, N., Kobayashi, H., Ohno, S., Ebana, Y., Tsukamoto, O., Ishino, S., Takuwa, A., Kioka, H., Yamashita, T., Hashimoto, N., Zankov, D.P., Shimizu, A., Asakura, M., Asanuma, H., Kato, H., Nishida, Y., Miyashita, Y., Shinomiya, H., Naiki, N., Hayashi, K., Makiyama, T., Ogita, H., Miura, K., Ueshima, H., Komuro, I., Yamagishi, M., Horie, M., Kawakami, K., Furukawa, T., Koizumi, A., Kurachi, Y., Sakata, Y., Minamino, T., Kitakaze, M., Takashima, S. (2019) Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation. Circulation. 139(18):2157-2169
- Skarsfeldt, M.A., Bomholtz, S.H., Lundegaard, P.R., Lopez-Izquierdo, A., Tristani-Firouzi, M., Bentzen, B.H. (2018) Atrium-specific ion channels in the zebrafish-A role of IKACh in atrial repolarization.. Acta physiologica (Oxford, England). 223(3):e13049
1 - 4 of 4
Show