Gene
cobll1a
- ID
- ZDB-GENE-120215-171
- Name
- cordon-bleu WH2 repeat protein-like 1a
- Symbol
- cobll1a Nomenclature History
- Previous Names
-
- si:dkey-43i4.1
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Acts upstream of or within lipid homeostasis; regulation of lipoprotein metabolic process; and retinoic acid metabolic process. Is expressed in brain; digestive system; head; and notochord. Orthologous to human COBLL1 (cordon-bleu WH2 repeat protein like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Zeng et al., 2024
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Zeng et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cobll1a | Zeng et al., 2024 | |
| CRISPR2-cobll1a | Zeng et al., 2024 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cordon-bleu, ubiquitin-like domain | Protein cordon-bleu-like | Raf-like Ras-binding |
|---|---|---|---|---|---|
| UniProtKB:A0A8M2BD63 | InterPro | 737 | |||
| UniProtKB:A0A8M9QFR6 | InterPro | 736 | |||
| UniProtKB:A0A8M9QFS0 | InterPro | 334 | |||
| UniProtKB:A0A8M9Q064 | InterPro | 733 | |||
| UniProtKB:A0A8M9PMI1 | InterPro | 734 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cobll1a-201
(1)
|
Ensembl | 494 nt | ||
| mRNA |
cobll1a-202
(1)
|
Ensembl | 2,929 nt | ||
| mRNA |
cobll1a-203
(1)
|
Ensembl | 621 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-43I4 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068221891 (1) | 2963 nt | ||
| Genomic | GenBank:CR396591 (1) | 113989 nt | ||
| Polypeptide | UniProtKB:A0A8M2BD63 (1) | 737 aa |
- Zeng, T., Lv, J., Liang, J., Xie, B., Liu, L., Tan, Y., Zhu, J., Jiang, J., Xie, H. (2024) Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway. Frontiers in cell and developmental biology. 12:13813621381362
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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