ZFIN is now using GRCz12tu for Genomic Data
Gene
znf644b
- ID
- ZDB-GENE-120214-23
- Name
- zinc finger protein 644b
- Symbol
- znf644b Nomenclature History
- Previous Names
-
- si:ch211-15l16.2
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within camera-type eye photoreceptor cell differentiation; epigenetic regulation of gene expression; and neuron cellular homeostasis. Predicted to be active in nucleus. Is expressed in head; midbrain; optic cup; presumptive retinal pigmented epithelium; and trunk. Human ortholog(s) of this gene implicated in myopia. Orthologous to human ZNF644 (zinc finger protein 644).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Olsen et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Olsen et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6068 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa7038 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14999 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15981 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| uot5 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| uot6 | Allele with one delins | Unknown | Unknown | CRISPR | |
| uot7 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-znf644b | Olsen et al., 2016 | |
| MO1-znf644b | N/A | Olsen et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Transcriptional Regulators with Zinc Finger Domains | Wiz, C-terminal zinc finger | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BG18 | InterPro | 1235 | ||||
| UniProtKB:A0A8M9Q5E5 | InterPro | 1235 | ||||
| UniProtKB:A0A8M9PMS3 | InterPro | 1267 | ||||
| UniProtKB:A0A8M9QAA3 | InterPro | 1267 | ||||
| UniProtKB:A0AB32TJK0 | InterPro | 1254 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
znf644b-201
(1)
|
Ensembl | 10,495 nt | ||
| mRNA |
znf644b-202
(1)
|
Ensembl | 6,483 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-15L16 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_073954090 (1) | GRCz12tu | 5298 nt | |
| Genomic | RefSeq:NW_018394642 (1) | GRCz12tu | ||
| Polypeptide | UniProtKB:A0A8M9PMS3 (1) | 1267 aa |
- Fernandez, J.P., Moreno-Mateos, M.A., Gohr, A., Miao, L., Chan, S.H., Irimia, M., Giraldez, A.J. (2018) RES complex is associated with intron definition and required for zebrafish early embryogenesis. PLoS Genetics. 14:e1007473
- Olsen, J.B., Wong, L., Deimling, S., Miles, A., Guo, H., Li, Y., Zhang, Z., Greenblatt, J.F., Emili, A., Tropepe, V. (2016) G9a and ZNF644 Physically Associate to Suppress Progenitor Gene Expression during Neurogenesis. Stem Cell Reports. 7(3):454-70
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