ZFIN is now using GRCz12tu for Genomic Data
Gene

slc16a2

ID
ZDB-GENE-120117-1
Name
solute carrier family 16 member 2
Symbol
slc16a2 Nomenclature History
Previous Names
  • MCT8 (1)
Type
protein_coding_gene
Location
Ambiguous Mapping Details/Browsers
Genome Assembly
GRCz12tu
Annotation Status
Current
Description
Enables thyroid hormone binding activity and thyroid hormone transmembrane transporter activity. Acts upstream of or within several processes, including nervous system development; optomotor response; and thyroid gland development. Predicted to be located in apical plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; digestive system; eye; and hindbrain neural keel. Used to study Allan-Herndon-Dudley syndrome. Human ortholog(s) of this gene implicated in Allan-Herndon-Dudley syndrome and intellectual disability. Orthologous to human SLC16A2 (solute carrier family 16 member 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
35 figures from 9 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With slc16a2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Allan-Herndon-Dudley syndrome Alliance Allan-Herndon-Dudley syndrome 300523
Associated With slc16a2 Via Experimental Models
Human Disease Fish Conditions Citations
Allan-Herndon-Dudley syndrome slc16a2biu4/biu4 standard conditions Zada et al., 2014
Allan-Herndon-Dudley syndrome slc16a2biu4/biu4; ck1Tg control Zada et al., 2016
Allan-Herndon-Dudley syndrome WT + MO3-slc16a2 standard conditions de Vrieze et al., 2014
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR020846 Major facilitator superfamily domain
Family IPR011701 Major facilitator superfamily
Family IPR050327 Proton-linked Monocarboxylate Transporter
Homologous_superfamily IPR036259 MFS transporter superfamily
Domain Details Per Protein
Protein Additional Resources Length Major facilitator superfamily Major facilitator superfamily domain MFS transporter superfamily Proton-linked Monocarboxylate Transporter
UniProtKB:G8XYX6 InterPro 526
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA slc16a2-201 (1)
Ensembl
Ensembl 1,581 nt
ZFIN BLAST
mRNA slc16a2-202 (1)
Ensembl
Ensembl 1,587 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Genome Browsers
Orthology
Comparative Orthology
Alliance
Citations
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