Gene
rbfox3a
- ID
- ZDB-GENE-111213-1
- Name
- RNA binding fox-1 homolog 3a
- Symbol
- rbfox3a Nomenclature History
- Previous Names
-
- rbfox3
- neun (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable mRNA binding activity. Predicted to be involved in nervous system development and regulation of alternative mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Located in nucleus. Is expressed in brain; heart; and spinal cord. Orthologous to human RBFOX3 (RNA binding fox-1 homolog 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Fox-1 C-terminal domain | FOX1, RNA recognition motif | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA binding protein fox-1 homolog 1-3 | RNA binding protein fox-1 homolog 1-like | RNA recognition motif domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QES8 | InterPro | 411 | |||||||
| UniProtKB:A0A8M9QET1 | InterPro | 345 | |||||||
| UniProtKB:A0A8M9PX73 | InterPro | 381 | |||||||
| UniProtKB:A0A8M9QN15 | InterPro | 387 | |||||||
| UniProtKB:A0A8M9Q953 | InterPro | 345 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rbfox3a-201
(1)
|
Ensembl | 1,104 nt | ||
| mRNA |
rbfox3a-202
(1)
|
Ensembl | 7,208 nt | ||
| mRNA |
rbfox3a-203
(1)
|
Ensembl | 1,589 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-7L12 | ||
| Contained in | BAC | CH73-169K22 | ZFIN Curated Data | |
| Contained in | BAC | CH73-237C20 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021480373 (1) | 5369 nt | ||
| Genomic | GenBank:BX936416 (1) | 214763 nt | ||
| Polypeptide | UniProtKB:A0A8M9QJ91 (1) | 429 aa |
- Antón-Galindo, E., Adel, M.R., García-González, J., Leggieri, A., López-Blanch, L., Irimia, M., Norton, W.H.J., Brennan, C.H., Fernàndez-Castillo, N., Cormand, B. (2024) Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in two zebrafish models. Translational psychiatry. 14:9999
- Rani, R., Sri, N.S., Medishetti, R., Chatti, K., Sevilimedu, A. (2024) Loss of FMRP affects ovarian development and behaviour through multiple pathways in a zebrafish model of fragile X syndrome. Human molecular genetics. 33(16):1391-1405
- Azbazdar, Y., Poyraz, Y.K., Ozalp, O., Nazli, D., Ipekgil, D., Cucun, G., Ozhan, G. (2023) High-fat diet feeding triggers a regenerative response in the adult zebrafish brain. Molecular neurobiology. 60(5):2486-2506
- Zhang, T., Alonzo, I., Stubben, C., Geng, Y., Herdman, C., Chandler, N., Doane, K.P., Pluimer, B.R., Trauger, S.A., Peterson, R.T. (2023) A zebrafish model of Combined Saposin Deficiency identifies acid sphingomyelinase as a potential therapeutic target. Disease models & mechanisms. 16(7):
- Aggarwal, K., Kuka, T.P., Banik, M., Medellin, B.P., Ngo, C.Q., Xie, D., Fernandes, Y., Dangerfield, T.L., Ye, E., Bouley, B., Johnson, K.A., Zhang, Y.J., Eberhart, J.K., Que, E.L. (2020) Visible light mediated bidirectional control over carbonic anhydrase activity in cells and in vivo using azobenzene sulfonamides. Journal of the American Chemical Society. 142(34):14522-14531
- Erbaba, B., Burhan, Ö.P., Şerifoğlu, N., Muratoğlu, B., Kahveci, F., Adams, M.M., Arslan-Ergül, A. (2020) Zebrafish brain RNA sequencing reveals that cell adhesion molecules are critical in brain aging. Neurobiology of aging. 94:164-175
- Klingseisen, A., Ristoiu, A.M., Kegel, L., Sherman, D.L., Rubio-Brotons, M., Almeida, R.G., Koudelka, S., Benito-Kwiecinski, S.K., Poole, R.J., Brophy, P.J., Lyons, D.A. (2019) Oligodendrocyte Neurofascin Independently Regulates Both Myelin Targeting and Sheath Growth in the CNS. Developmental Cell. 51(6):730-744.e6
- Won, M., Lee, S., Choi, S., Ro, H., Kim, K.J., Kim, J.H., Kim, K.E., Kim, K.K. (2016) Identification and characterization of the RNA-binding protein Rbfox3 in zebrafish embryo. Biochemical and Biophysical Research Communications. 472(2):373-8
- Frese, K.S., Meder, B., Keller, A., Just, S., Haas, J., Vogel, B., Fischer, S., Backes, C., Matzas, M., Köhler, D., Benes, V., Katus, H.A., Rottbauer, W. (2015) RNA splicing regulated by RBFOX1 is essential for cardiac function in zebrafish. Journal of Cell Science. 128(16):3030-40
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