Gene
ambra1a
- ID
- ZDB-GENE-111104-2
- Name
- autophagy/beclin-1 regulator 1a
- Symbol
- ambra1a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable protein phosphatase activator activity and ubiquitin-like ligase-substrate adaptor activity. Acts upstream of or within several processes, including gonad development; locomotory behavior; and skeletal muscle fiber development. Predicted to be located in several cellular components, including autophagosome; focal adhesion; and mitochondrion. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in several structures, including blastodisc; liver; oral cavity; pleuroperitoneal region; and tail bud. Orthologous to human AMBRA1 (autophagy and beclin 1 regulator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 29 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a223 | Allele with one delins | Unknown | Unknown | CRISPR | |
| ia35 | Allele with one insertion | Exon 4 | Unknown | CRISPR | |
| sa10425 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11767 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa14147 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21027 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40965 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 7 of 7
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Family | IPR052596 | Activating Molecule in BECN1-Regulated Autophagy |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
1 - 5 of 5
Domain Details Per Protein
| Protein | Additional Resources | Length | Activating Molecule in BECN1-Regulated Autophagy | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:E7FAG6 | InterPro | 1315 | |||||
| UniProtKB:A0A8M1RIC3 | InterPro | 1344 |
1 - 2 of 2
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ambra1a-201
(1)
|
Ensembl | 6,776 nt | ||
| mRNA |
ambra1a-202
(1)
|
Ensembl | 3,220 nt | ||
| ncRNA |
ambra1a-203
(1)
|
Ensembl | 3,870 nt | ||
| ncRNA |
ambra1a-204
(1)
|
Ensembl | 2,842 nt |
1 - 4 of 4
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance
- Xin, S., Zhang, M., Li, P., Wang, L., Zhang, X., Zhang, S., Mu, Z., Lin, H., Li, X., Liu, K. (2024) Marine-Fungus-Derived Natural Compound 4-Hydroxyphenylacetic Acid Induces Autophagy to Exert Antithrombotic Effects in Zebrafish. Marine drugs. 22(4):
- Fontana, C.M., Terrin, F., Facchinello, N., Meneghetti, G., Dinarello, A., Gambarotto, L., Zuccarotto, A., Caichiolo, M., Brocca, G., Verin, R., Nazio, F., Carnevali, O., Cecconi, F., Bonaldo, P., Dalla Valle, L. (2023) Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction. Biological research. 56:1919
- Ren, Q., Jiang, X., Zhang, S., Gao, X., Paudel, Y.N., Zhang, P., Wang, R., Liu, K., Jin, M. (2022) Neuroprotective effect of YIAEDAER peptide against Parkinson's disease like pathology in zebrafish. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 147:112629
- Revathidevi, S., Hosomichi, K., Natsume, T., Nakaoka, H., Fujito, N.T., Akatsuka, H., Sato, T., Munirajan, A.K., Inoue, I. (2022) AMBRA1 p.Gln30Arg Mutation, Identified in a Cowden Syndrome Family, Exhibits Hyperproliferative Potential in hTERT-RPE1 Cells. International Journal of Molecular Sciences. 23(19):
- Sun, C., Zhang, S., Ba, S., Dang, J., Ren, Q., Zhu, Y., Liu, K., Jin, M. (2022) Eucommia ulmoides Olive Male Flower Extracts Ameliorate Alzheimer's Disease-Like Pathology in Zebrafish via Regulating Autophagy, Acetylcholinesterase, and the Dopamine Transporter. Frontiers in molecular neuroscience. 15:901953
- Ji, X., Wang, B., Paudel, Y.N., Li, Z., Zhang, S., Mou, L., Liu, K., Jin, M. (2021) Protective Effect of Chlorogenic Acid and Its Analogues on Lead-Induced Developmental Neurotoxicity Through Modulating Oxidative Stress and Autophagy. Frontiers in molecular biosciences. 8:655549
- Wang, H., Qiu, T.X., Lu, J.F., Liu, H.W., Hu, L., Liu, L., Chen, J. (2021) Potential aquatic environmental risks of trifloxystrobin: Enhancement of virus susceptibility in zebrafish through initiation of autophagy. Zoological research. 42:339-349
- Ai, X., Ye, Z., Yao, Y., Xiao, J., You, C., Xu, J., Huang, X., Zhong, J., Fan, M., Song, X., Shi, H., Zhang, D., Zhao, C. (2020) Endothelial Autophagy: an Effective Target for Radiation-induced Cerebral Capillary Damage. Scientific Reports. 10:614
- Bello-Perez, M., Pereiro, P., Coll, J., Novoa, B., Perez, L., Falco, A. (2020) Zebrafish C-reactive protein isoforms inhibit SVCV replication by blocking autophagy through interactions with cell membrane cholesterol. Scientific Reports. 10:566
- Li, X., Dang, J., Li, Y., Wang, L., Li, N., Liu, K., Jin, M. (2020) Developmental neurotoxicity fingerprint of silica nanoparticles at environmentally relevant level on larval zebrafish using a neurobehavioral-phenomics-based biological warning method. The Science of the total environment. 752:141878
1 - 10 of 29
Show