ZFIN is now using GRCz12tu for Genomic Data
Gene
duoxa
- ID
- ZDB-GENE-111007-1
- Name
- dual oxidase maturation factor
- Symbol
- duoxa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Acts upstream of or within thyroid gland development. Is expressed in brain; intestine; thyroid follicle; thyroid primordium; and ultimobranchial body. Human ortholog(s) of this gene implicated in thyroid dyshormonogenesis 5. Orthologous to several human genes including DUOXA2 (dual oxidase maturation factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-duoxa | (2) | |
| CRISPR2-duoxa | Trubiroha et al., 2018 | |
| CRISPR3-duoxa | Salis et al., 2021 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| thyroid dyshormonogenesis 5 | Alliance | Thyroid dyshormonogenesis 5 | 274900 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR018469 | Dual oxidase maturation factor |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Dual oxidase maturation factor |
|---|---|---|---|
| UniProtKB:A0A8M1RI64 | InterPro | 329 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
duoxa1-201
(1)
|
Ensembl | 2,201 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
No data available
- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_073943305 (1) | GRCz12tu | 1829 nt | |
| Genomic | GenBank:CABZ01038908 (1) | |||
| Polypeptide | UniProtKB:A0A8M1RI64 (2) | 329 aa |
- Comparative Orthology
- Alliance
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Zasu, A., Hishima, F., Thauvin, M., Yoneyama, Y., Kitani, Y., Hakuno, F., Volovitch, M., Takahashi, S.I., Vriz, S., Rampon, C., Kamei, H. (2022) NADPH-Oxidase Derived Hydrogen Peroxide and Irs2b Facilitate Re-oxygenation-Induced Catch-Up Growth in Zebrafish Embryo. Frontiers in endocrinology. 13:929668
- Salis, P., Roux, N., Huang, D., Marcionetti, A., Mouginot, P., Reynaud, M., Salles, O., Salamin, N., Pujol, B., Parichy, D.M., Planes, S., Laudet, V. (2021) Thyroid hormones regulate the formation and environmental plasticity of white bars in clownfishes. Proceedings of the National Academy of Sciences of the United States of America. 118(23):
- Giusti, N., Gillotay, P., Trubiroha, A., Opitz, R., Dumont, J.E., Costagliola, S., De Deken, X. (2019) Inhibition of the thyroid hormonogenic H2O2 production by Duox/DuoxA in zebrafish reveals VAS2870 as a new goitrogenic compound. Molecular and Cellular Endocrinology. 500:110635
- Trubiroha, A., Gillotay, P., Giusti, N., Gacquer, D., Libert, F., Lefort, A., Haerlingen, B., De Deken, X., Opitz, R., Costagliola, S. (2018) A Rapid CRISPR/Cas-based Mutagenesis Assay in Zebrafish for Identification of Genes Involved in Thyroid Morphogenesis and Function. Scientific Reports. 8:5647
- Opitz, R., Maquet, E., Zoenen, M., Dadhich, R., and Costagliola, S. (2011) TSH Receptor Function Is Required for Normal Thyroid Differentiation in Zebrafish. Molecular endocrinology (Baltimore, Md.). 25(9):1579-99
- Flores, M.V., Crawford, K.C., Pullin, L.M., Hall, C.J., Crosier, K.E., and Crosier, P.S. (2010) Dual oxidase in the intestinal epithelium of zebrafish larvae has anti-bacterial properties. Biochemical and Biophysical Research Communications. 400(1):164-168
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