Gene
gdnfb
- ID
- ZDB-GENE-110609-2
- Name
- glial cell derived neurotrophic factor b
- Symbol
- gdnfb Nomenclature History
- Previous Names
-
- si:ch73-311f13.2
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable growth factor activity. Predicted to be involved in negative regulation of neuron apoptotic process; peripheral nervous system development; and positive regulation of branching involved in ureteric bud morphogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in testis. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; Parkinsonism; alcohol dependence; alcohol use disorder; and heroin dependence. Orthologous to human GDNF (glial cell derived neurotrophic factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Doretto et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Hirschsprung disease, susceptibility to, 3} | 613711 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | Glial cell line-derived neurotrophic factor family | Transforming growth factor-beta, C-terminal |
|---|---|---|---|---|---|
| UniProtKB:A0A8M3ARX4 | InterPro | 196 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-311F13 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009301191 (1) | 1081 nt | ||
| Genomic | GenBank:FP016143 (2) | 97328 nt | ||
| Polypeptide | UniProtKB:A0A8M3ARX4 (1) | 196 aa |
- Doretto, L.B., Butzge, A.J., Nakajima, R.T., Martinez, E.R.M., de Souza, B.M., Rodrigues, M.D.S., Rosa, I.F., Ricci, J.M.B., Tovo-Neto, A., Costa, D.F., Malafaia, G., Shao, C., Nóbrega, R.H. (2022) Gdnf Acts as a Germ Cell-Derived Growth Factor and Regulates the Zebrafish Germ Stem Cell Niche in Autocrine- and Paracrine-Dependent Manners. Cells. 11(8):
- Hätinen, T., Holm, L., and Airaksinen, M.S. (2007) Loss of neurturin in frog — Comparative genomics study of GDNF family ligand-receptor pairs. Molecular and cellular neurosciences. 34(2):155-167
- Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466
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