Gene
ago1
- ID
- ZDB-GENE-110606-3
- Name
- argonaute RISC component 1
- Symbol
- ago1 Nomenclature History
- Previous Names
-
- Ago1 (1)
- eif2c1
- si:ch211-119n15.3
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable miRNA binding activity and single-stranded RNA binding activity. Predicted to be involved in pre-miRNA processing and regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to act upstream of or within regulation of translation and regulatory ncRNA-mediated gene silencing. Predicted to be located in P-body. Predicted to be part of RISC complex. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Is expressed in several structures, including eye; fin; integument; pleuroperitoneal region; and post-vent region. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human AGO1 (argonaute RISC component 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizures | 620292 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Argonaute-like, PIWI domain | Argonaute, linker 1 domain | Argonaute linker 2 domain | PAZ domain | PAZ domain superfamily | Piwi domain | Protein argonaute, Mid domain | Protein argonaute, N-terminal | Ribonuclease H-like superfamily | Ribonuclease H superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:X1WG39 | InterPro | 858 | ||||||||||
| UniProtKB:A0A8M2B4V2 | InterPro | 871 | ||||||||||
| UniProtKB:K4I6K9 | InterPro | 858 |
1 - 3 of 3
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-52F24 | ZFIN Curated Data | |
| Contained in | BAC | CH211-119N15 |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001317223 (1) | |||
| Genomic | GenBank:FQ323156 (1) | 108329 nt | ||
| Polypeptide | UniProtKB:A0A8M2B4V2 (1) | 871 aa |