Gene
bcl2b
- ID
- ZDB-GENE-110411-185
- Name
- BCL2 apoptosis regulator b
- Symbol
- bcl2b Nomenclature History
- Previous Names
-
- si:dkey-217f4.3 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have protein heterodimerization activity and protein homodimerization activity. Predicted to be involved in extrinsic apoptotic signaling pathway in absence of ligand; intrinsic apoptotic signaling pathway in response to DNA damage; and negative regulation of intrinsic apoptotic signaling pathway. Predicted to localize to mitochondrial outer membrane. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; and prostate cancer. Orthologous to human BCL2 (BCL2 apoptosis regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Leukemia/lymphoma, B-cell, 2 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020717 | Apoptosis regulator, Bcl-2, BH1 motif, conserved site |
| Conserved_site | IPR020726 | Apoptosis regulator, Bcl-2, BH2 motif, conserved site |
| Domain | IPR003093 | Apoptosis regulator, Bcl-2 protein, BH4 |
| Domain | IPR046371 | Bcl-2, Bcl-2 homology region 1-3 |
| Family | IPR002475 | Bcl2-like |
| Family | IPR013279 | Apoptosis regulator, Bcl-X |
| Family | IPR026298 | Bcl-2 family |
| Homologous_superfamily | IPR036834 | Bcl-2-like superfamily |
Domain Details Per Protein
| Protein | Length | Apoptosis regulator, Bcl-2, BH1 motif, conserved site | Apoptosis regulator, Bcl-2, BH2 motif, conserved site | Apoptosis regulator, Bcl-2 protein, BH4 | Apoptosis regulator, Bcl-X | Bcl-2, Bcl-2 homology region 1-3 | Bcl-2 family | Bcl2-like | Bcl-2-like superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F8W266
|
209 |
Interactions and Pathways
No data available
Plasmids
No data available