Gene
itga4
- ID
- ZDB-GENE-110411-108
- Name
- integrin alpha 4
- Symbol
- itga4 Nomenclature History
- Previous Names
-
- si:ch73-119a20.1
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor activity. Acts upstream of or within blood vessel development; endocardial cell differentiation; and regulation of vascular permeability. Predicted to be located in membrane. Predicted to be part of integrin alpha4-beta1 complex and integrin alpha4-beta7 complex. Predicted to be active in cell surface. Is expressed in several structures, including cerebellum; intermediate cell mass of mesoderm; mid cerebral vein; notochord; and trunk. Human ortholog(s) of this gene implicated in autism spectrum disorder and pancreatic cancer. Orthologous to human ITGA4 (integrin subunit alpha 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018184 | Integrin alpha chain, C-terminal cytoplasmic region, conserved site |
| Domain | IPR013649 | Integrin alpha, first immunoglubulin-like domain |
| Domain | IPR048285 | Integrin alpha, second immunoglobulin-like domain |
| Domain | IPR048286 | Integrin alpha, third immunoglobulin-like domain |
| Family | IPR000413 | Integrin alpha chain |
| Homologous_superfamily | IPR028994 | Integrin alpha, N-terminal |
| Homologous_superfamily | IPR032695 | Integrin domain superfamily |
| Repeat | IPR013517 | FG-GAP repeat |
| Repeat | IPR013519 | Integrin alpha beta-propellor |
Domain Details Per Protein
| Protein | Additional Resources | Length | FG-GAP repeat | Integrin alpha beta-propellor | Integrin alpha chain | Integrin alpha chain, C-terminal cytoplasmic region, conserved site | Integrin alpha, first immunoglubulin-like domain | Integrin alpha, N-terminal | Integrin alpha, second immunoglobulin-like domain | Integrin alpha, third immunoglobulin-like domain | Integrin domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q587 | InterPro | 752 | |||||||||
| UniProtKB:A0A0R4ICS1 | InterPro | 1018 |
Interactions and Pathways
No data available
Plasmids
No data available