Gene
h6pd
- ID
- ZDB-GENE-110408-60
- Name
- hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
- Symbol
- h6pd Nomenclature History
- Previous Names
-
- si:dkey-148l2.3
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have 6-phosphogluconolactonase activity; NADP binding activity; and glucose-6-phosphate dehydrogenase activity. Predicted to be involved in glucose metabolic process and pentose-phosphate shunt. Human ortholog(s) of this gene implicated in cortisone reductase deficiency; cortisone reductase deficiency 1; and multiple sclerosis. Orthologous to human H6PD (hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cortisone reductase deficiency 1 | Alliance | Cortisone reductase deficiency 1 | 604931 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR019796 | Glucose-6-phosphate dehydrogenase, active site |
| Domain | IPR005900 | 6-phosphogluconolactonase, DevB-type |
| Domain | IPR006148 | Glucosamine/galactosamine-6-phosphate isomerase |
| Domain | IPR022674 | Glucose-6-phosphate dehydrogenase, NAD-binding |
| Domain | IPR022675 | Glucose-6-phosphate dehydrogenase, C-terminal |
| Family | IPR001282 | Glucose-6-phosphate dehydrogenase |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
| Homologous_superfamily | IPR037171 | NagB/RpiA transferase-like |
Domain Details Per Protein
| Protein | Length | 6-phosphogluconolactonase, DevB-type | Glucosamine/galactosamine-6-phosphate isomerase | Glucose-6-phosphate dehydrogenase | Glucose-6-phosphate dehydrogenase, active site | Glucose-6-phosphate dehydrogenase, C-terminal | Glucose-6-phosphate dehydrogenase, NAD-binding | NAD(P)-binding domain superfamily | NagB/RpiA transferase-like |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7FGT2
|
791 |
Interactions and Pathways
No data available
Plasmids
No data available