smoc1

ID

ZDB-GENE-110310-7

Name

SPARC related modular calcium binding 1

Symbol

smoc1 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable extracellular matrix binding activity and heparin binding activity. Acts upstream of or within optic cup morphogenesis involved in camera-type eye development; pectoral fin morphogenesis; and positive regulation of BMP signaling pathway. Predicted to be active in basement membrane and extracellular space. Is expressed in brain; head; optic cup; optic vesicle; and pectoral fin. Human ortholog(s) of this gene implicated in microphthalmia with limb anomalies. Orthologous to human SMOC1 (SPARC related modular calcium binding 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With smoc1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
microphthalmia with limb anomalies	Alliance	Microphthalmia with limb anomalies	206920

Associated With smoc1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018247	EF-Hand 1, calcium-binding site
Domain	IPR000716	Thyroglobulin type-1
Domain	IPR002350	Kazal domain
Domain	IPR019577	SPARC/Testican, calcium-binding domain
Domain	IPR037639	SMOC-1, extracellular calcium-binding domain
Family	IPR051950	Developmental regulator and protease inhibitor
Homologous_superfamily	IPR011992	EF-hand domain pair
Homologous_superfamily	IPR036058	Kazal domain superfamily
Homologous_superfamily	IPR036857	Thyroglobulin type-1 superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9PE18	InterPro	505
UniProtKB:A0A8M9PNJ3	InterPro	503
UniProtKB:A0A8M9P007	InterPro	514
UniProtKB:A0A8M9P8R7	InterPro	488
UniProtKB:A0A8M9P010	InterPro	499
UniProtKB:A0A8M9PNJ7	InterPro	467
UniProtKB:A0A8M9PKH8	InterPro	516
UniProtKB:A0A8M9PE24	InterPro	486
UniProtKB:A0A8M9P8R3	InterPro	505
UniProtKB:A0A8M9PKI3	InterPro	502
UniProtKB:E7EDQ9	InterPro	461
UniProtKB:A0AB32T744	InterPro	505
UniProtKB:A0AB32T7A4	InterPro	504
UniProtKB:A0AB32T8L5	InterPro	503
UniProtKB:A0AB32TAI1	InterPro	487
UniProtKB:A0AB32TAR2	InterPro	506
UniProtKB:A0AC58HLU8	InterPro	494
UniProtKB:A0AC58HLU9	InterPro	495
UniProtKB:A0AC58HLV0	InterPro	493
UniProtKB:A0AC58HLV2	InterPro	489
UniProtKB:A0AC58HLV6	InterPro	489
UniProtKB:A0AC58HLV8	InterPro	493
UniProtKB:A0AC58HLV9	InterPro	491
UniProtKB:A0AC58HLW2	InterPro	492
UniProtKB:A0AC58HLW3	InterPro	486
UniProtKB:A0AC58HLW4	InterPro	504
UniProtKB:A0AC58HLW5	InterPro	486
UniProtKB:A0AC58HLW6	InterPro	502
UniProtKB:A0AC58HLW7	InterPro	477
UniProtKB:A0AC58HLW9	InterPro	503
UniProtKB:A0AC58HLX0	InterPro	497
UniProtKB:A0AC58HLX1	InterPro	477
UniProtKB:A0AC58HLX2	InterPro	485
UniProtKB:A0AC58HLX3	InterPro	478
UniProtKB:A0AC58HLX4	InterPro	485
UniProtKB:A0AC58HLX5	InterPro	492
UniProtKB:A0AC58HLX6	InterPro	488
UniProtKB:A0AC58HLX7	InterPro	488
UniProtKB:A0AC58HLX8	InterPro	483
UniProtKB:A0AC58HLX9	InterPro	494
UniProtKB:A0AC58HLY1	InterPro	474
UniProtKB:A0AC58HLY2	InterPro	474
UniProtKB:A0AC58HLY3	InterPro	503
UniProtKB:A0AC58HLY4	InterPro	465
UniProtKB:A0AC58HLY7	InterPro	476
UniProtKB:A0AC58HLY8	InterPro	487
UniProtKB:A0AC58HLY9	InterPro	476
UniProtKB:A0AC58HLZ0	InterPro	487
UniProtKB:A0AC58HLZ1	InterPro	475
UniProtKB:A0AC58HLZ2	InterPro	500
UniProtKB:A0AC58HLZ5	InterPro	486
UniProtKB:A0AC58HM01	InterPro	491
UniProtKB:A0AC58HM02	InterPro	475
UniProtKB:A0AC58HM07	InterPro	464
UniProtKB:A0AC58HM09	InterPro	472