Gene

akap12a

ID
ZDB-GENE-110310-3
Name
A kinase (PRKA) anchor protein 12a
Symbol
akap12a Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to enable calmodulin binding activity and protein kinase A binding activity. Predicted to be involved in regulation of protein kinase A signaling and signal transduction. Predicted to act upstream of or within positive regulation of protein kinase A signaling and regulation of protein kinase C signaling. Predicted to be located in membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in chronic kidney disease; colorectal carcinoma; and juvenile myelomonocytic leukemia. Orthologous to human AKAP12 (A-kinase anchoring protein 12).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa17436Allele with one point mutationUnknownPremature StopENU
Zebrafish International Resource Center (ZIRC) (order this)
European Zebrafish Resource Center (EZRC) (order this)
sa28800Allele with one point mutationUnknownPremature StopENU
European Zebrafish Resource Center (EZRC) (order this)
Zebrafish International Resource Center (ZIRC) (order this)
sa32118Allele with one point mutationUnknownPremature StopENU
Zebrafish International Resource Center (ZIRC) (order this)
European Zebrafish Resource Center (EZRC) (order this)
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Sequence Targeting Reagents
No data available
Human Disease
Associated With akap12a Human Ortholog
No data available
Associated With akap12a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001573 A kinase-anchoring protein AKAP5 and AKAP12, calmodulin (CaM)-binding motif
Family IPR028540 A-kinase anchor protein 12
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Domain Details Per Protein
Protein Additional Resources Length A kinase-anchoring protein AKAP5 and AKAP12, calmodulin (CaM)-binding motif A-kinase anchor protein 12
UniProtKB:E7F983 InterPro 3023
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 17
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA akap12a-201 (1)
Ensembl
Ensembl 10,675 nt
ZFIN BLAST
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-204M6ZFIN Curated Data
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Sequences
Type Accession # Sequence Length (nt/aa) Analysis
RNARefSeq:XM_005158609 (1)13273 nt
ZFIN BLASTNCBI BLASTEnsemblUCSC BLAT
GenomicGenBank:BX088649 (1)163494 nt
MegaBLASTEnsembl
PolypeptideUniProtKB:E7F983 (1)3023 aa
ZFIN BLASTSIB BLASTEnsembl Protein Blast
Orthology
Comparative Orthology
Alliance
Species Symbol Chromosome Accession # Evidence
HumanAKAP126
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseAkap1210
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
No data available
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