Gene
smc6
- ID
- ZDB-GENE-110303-1
- Name
- structural maintenance of chromosomes 6
- Symbol
- smc6 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable damaged DNA binding activity and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination. Predicted to act upstream of or within DNA recombination and double-strand break repair. Predicted to be located in chromosome. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus and site of double-strand break. Is expressed in head and post-vent region. Orthologous to human SMC6 (structural maintenance of chromosomes 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Li et al., 2021
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | P-loop containing nucleoside triphosphate hydrolase | RecF/RecN/SMC, N-terminal |
---|---|---|---|---|
UniProtKB:A0A8M9Q634 | InterPro | 1097 | ||
UniProtKB:A0A8M2B5G4 | InterPro | 1094 | ||
UniProtKB:X1WGQ9 | InterPro | 1093 | ||
UniProtKB:A0A8M9Q235 | InterPro | 678 | ||
UniProtKB:A0A8M6YTX5 | InterPro | 674 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-189E2 | ZFIN Curated Data | |
Contained in | BAC | CH211-191L23 | ZFIN Curated Data | |
Contained in | BAC | DKEY-37O3 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_021473054 (1) | 3729 nt | ||
Genomic | GenBank:AL929338 (1) | 179399 nt | ||
Polypeptide | UniProtKB:A0A8M9PV42 (1) | 1098 aa |
- Zhang, Y., Li, R., Li, H., Huang, Y., Mei, Y., Zheng, Y., Guo, Y., Zhou, Z., Yong, Z., Zhao, Y., Dong, W., Gao, J., Cao, X. (2024) Morpho-histological and Transcriptome Analysis Reveal the Unreduced Sperm Formation Mechanism in cdk1-Depletion Zebrafish. Marine biotechnology (New York, N.Y.). 26(6):1206-1218
- Li, J., Liu, F., Lv, Y., Sun, K., Zhao, Y., Reilly, J., Zhang, Y., Tu, J., Yu, S., Liu, X., Qin, Y., Huang, Y., Gao, P., Jia, D., Chen, X., Han, Y., Shu, X., Luo, D., Tang, Z., Liu, M. (2021) Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing. Nucleic acids research. 49(4):2027-2043
- Gao, L., Yuan, Z., Zhou, T., Yang, Y., Gao, D., Dunham, R., Liu, Z. (2019) FOXO genes in channel catfish and their response after bacterial infection. Developmental and comparative immunology. 97:38-44
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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