Gene

adamts3

ID

ZDB-GENE-110223-1

Name

ADAM metallopeptidase with thrombospondin type 1 motif, 3

Symbol

adamts3 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have metalloendopeptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in Hennekam syndrome. Is expressed in several structures, including digestive system; nervous system; otic vesicle; pleuroperitoneal region; and thymus. Orthologous to human ADAMTS3 (ADAM metallopeptidase with thrombospondin type 1 motif 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Jayadev et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adamts3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Hennekam lymphangiectasia-lymphedema syndrome 3	618154

Associated With adamts3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001590	Peptidase M12B, ADAM/reprolysin
Domain	IPR002870	Peptidase M12B, propeptide
Domain	IPR010294	ADAMTS/ADAMTS-like, Spacer 1
Domain	IPR010909	PLAC
Domain	IPR041645	ADAMTS, cysteine-rich domain 2
Domain	IPR045371	ADAMTS/ADAMTS-like, cysteine-rich domain 3
Family	IPR013273	ADAMTS/ADAMTS-like
Homologous_superfamily	IPR024079	Metallopeptidase, catalytic domain superfamily
Homologous_superfamily	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily
Repeat	IPR000884	Thrombospondin type-1 (TSP1) repeat

Domain Details Per Protein

Protein	Length	ADAMTS/ADAMTS-like	ADAMTS/ADAMTS-like, cysteine-rich domain 3	ADAMTS/ADAMTS-like, Spacer 1	ADAMTS, cysteine-rich domain 2	Metallopeptidase, catalytic domain superfamily	Peptidase M12B, ADAM/reprolysin	Peptidase M12B, propeptide	PLAC	Thrombospondin type-1 (TSP1) repeat	Thrombospondin type-1 (TSP1) repeat superfamily
UniProtKB:A0A8M9PJM4 InterPro	1192
UniProtKB:S5RVW8 InterPro	1164
UniProtKB:A0A8M6Z0H1 InterPro	802

Transcripts

Genome Browsers

NCBI

No data available

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations