Gene
ctnnd1
- ID
- ZDB-GENE-110208-9
- Name
- catenin (cadherin-associated protein), delta 1
- Symbol
- ctnnd1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable cadherin binding activity. Acts upstream of or within several processes, including cell migration involved in gastrulation; mesodermal cell migration; and posterior lateral line neuromast primordium migration. Predicted to be located in anchoring junction. Predicted to be active in several cellular components, including adherens junction; nucleus; and plasma membrane. Is expressed in Meckel's cartilage and oral epithelium. Human ortholog(s) of this gene implicated in blepharocheilodontic syndrome 2. Orthologous to human CTNND1 (catenin delta 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa14184 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31222 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| uab302 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| zko827a | Allele with one deletion | Unknown | Unknown | CRISPR | |
| zko827b | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ctnnd1 | (2) | |
| CRISPR2-ctnnd1 | (2) | |
| CRISPR3-ctnnd1 | (2) | |
| CRISPR4-ctnnd1 | (2) | |
| CRISPR5-ctnnd1 | (2) | |
| MO1-ctnnd1 | N/A | Hsu et al., 2012 |
| MO2-ctnnd1 | N/A | Hsu et al., 2012 |
| MO3-ctnnd1 | N/A | (3) |
| MO4-ctnnd1 | N/A | Mizoguchi et al., 2017 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| blepharocheilodontic syndrome 2 | Alliance | Blepharocheilodontic syndrome 2 | 617681 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo | Armadillo-like helical | Armadillo-type fold | Plakophilin/Delta catenin |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q693 | InterPro | 875 | ||||
| UniProtKB:A0A286Y8C1 | InterPro | 931 | ||||
| UniProtKB:A0A8M3AK93 | InterPro | 914 | ||||
| UniProtKB:A0A8M9PZY3 | InterPro | 944 | ||||
| UniProtKB:F1R6C8 | InterPro | 908 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ctnnd1-201
(1)
|
Ensembl | 4,796 nt | ||
| mRNA |
ctnnd1-202
(1)
|
Ensembl | 424 nt | ||
| mRNA |
ctnnd1-204
(1)
|
Ensembl | 552 nt | ||
| mRNA |
ctnnd1-205
(1)
|
Ensembl | 4,730 nt | ||
| mRNA |
ctnnd1-206
(1)
|
Ensembl | 539 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-59P5 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009293418 (1) | 5191 nt | ||
| Genomic | GenBank:CR848663 (1) | 193836 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q686 (1) | 950 aa |
- Caetano da Silva, C., Macias Trevino, C., Mitchell, J., Murali, H., Tsimbal, C., Dalessandro, E., Carroll, S.H., Kochhar, S., Curtis, S.W., Cheng, C.H.E., Wang, F., Kutschera, E., Carstens, R.P., Xing, Y., Wang, K., Leslie, E.J., Liao, E.C. (2024) Functional analysis of ESRP1/2 gene variants and CTNND1 isoforms in orofacial cleft pathogenesis. Communications biology. 7:10401040
- Li, D., Tian, Y., Vona, B., Yu, X., Lin, J., Ma, L., Lou, S., Li, X., Zhu, G., Wang, Y., Du, M., Wang, L., Pan, Y. (2024) A TAF11 variant contributes to non-syndromic cleft lip only through modulating neural crest cell migration. Human molecular genetics. :
- Kupai, A., Nakahara, H., Voss, K.M., Hirano, M.S., Rodriguez, A., Lackey, D.L., Murayama, J.F., Mathieson, C.J., Shan, B., Horton, E.C., Curtis, G.H., Huang, J., Hille, M.B. (2022) Phosphorylation of serine residues S252, S268/S269, and S879 in p120 catenin activates migration of presomitic mesoderm in gastrulating zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(12):1952-1967
- Shan, B., Horton, E.C., Xu, S.C., Huntington, K.E., Kawano, D.K., Mendoza, C.L., Lin, L., Stafford, C.M., Allen, E.D., Huang, J., Nakahara, H., Greenstein, L.E., Hille, M.B. (2022) Dephosphorylation of Y228 and Y217 and phosphorylation of Y335 in p120 catenin activate convergent extension during zebrafish gastrulation. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(12):1934-1951
- DeLaurier, A., Howe, D.G., Ruzicka, L., Carte, A.N., Mishoe Hernandez, L., Wiggins, K.J., Gallati, M.M., Vanpelt, K., Loyo Rosado, F., Pugh, K.G., Shabdue, C.J., Jihad, K., Thyme, S.B., Talbot, J.C. (2021) ZebraShare: a new venue for rapid dissemination of zebrafish mutant data. PeerJ. 9:e11007
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Mizoguchi, T., Ikeda, S., Watanabe, S., Sugawara, M., Itoh, M. (2017) Mib1 contributes to persistent directional cell migration by regulating the Ctnnd1-Rac1 pathway. Proceedings of the National Academy of Sciences of the United States of America. 114(44):E9280-E9289
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lee, P.T., Zou, J., Holland, J.W., Martin, S.A., Scott, C.J., Kanellos, T., Secombes, C.J. (2015) Functional characterisation of a TLR accessory protein, UNC93B1, in Atlantic salmon (Salmo salar). Developmental and comparative immunology. 50(1):38-48
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