nup214

ID

ZDB-GENE-110203-3

Name

nucleoporin 214

Symbol

nup214 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable nuclear localization sequence binding activity. Predicted to be a structural constituent of nuclear pore. Acts upstream of or within with a negative effect on Notch signaling pathway. Predicted to be located in nucleus. Predicted to be part of nuclear pore. Is expressed in several structures, including central nervous system; fertilized egg; gonad; heart; and immune system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; acute myeloid leukemia; and brain disease. Orthologous to human NUP214 (nucleoporin 214).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Kindermann et al., 2019

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Kindermann et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nup214 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acute lymphoblastic leukemia	Alliance	Leukemia, T-cell acute lymphoblastic, somatic	613065
acute myeloid leukemia	Alliance	Leukemia, acute myeloid, somatic	601626
		{Encephalopathy, acute, infection-induced, susceptibility to, 9}	618426

Associated With nup214 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

No data available

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M6Z6M9	InterPro	2055
UniProtKB:A0AC58JMU9	InterPro	2054
UniProtKB:A0AC58JMV0	InterPro	2003
UniProtKB:A0AC58JMV1	InterPro	2004
UniProtKB:A0AC58JMW4	InterPro	2055