Gene
prodhb
- ID
- ZDB-GENE-101116-1
- Name
- proline dehydrogenase (oxidase) 1b
- Symbol
- prodhb Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable FAD binding activity and proline dehydrogenase activity. Predicted to be involved in L-proline catabolic process to L-glutamate. Predicted to act upstream of or within L-proline catabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in amino acid metabolic disorder; hyperprolinemia type 1; and schizophrenia 4. Orthologous to human PRODH (proline dehydrogenase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hyperprolinemia type 1 | Alliance | Hyperprolinemia, type I | 239500 |
| schizophrenia 4 | Alliance | {Schizophrenia, susceptibility to, 4} | 600850 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | FAD-linked oxidoreductase-like | Proline dehydrogenase domain | Proline oxidase family |
|---|---|---|---|---|---|
| UniProtKB:E7FEU8 | InterPro | ||||
| UniProtKB:A0A8M6Z0Q4 | InterPro | 603 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_017356230 (1) | 1976 nt | ||
| Genomic | GenBank:FP102464 (1) | 53471 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z0Q4 (1) | 603 aa |
- Comparative Orthology
- Alliance
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Guna, A., Butcher, N.J., Bassett, A.S. (2015) Comparative mapping of the 22q11.2 deletion region and the potential of simple model organisms. Journal of neurodevelopmental disorders. 7:18
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