Gene
tnfrsf18
- ID
- ZDB-GENE-101104-7
- Name
- tumor necrosis factor receptor superfamily, member 18
- Symbol
- tnfrsf18 Nomenclature History
- Previous Names
-
- gitr (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to be involved in positive regulation of cell adhesion. Predicted to be active in external side of plasma membrane. Is expressed in gut; kidney; spleen; and thymus. Orthologous to human TNFRSF18 (TNF receptor superfamily member 18).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Poulton et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa33941 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-tnfrsf18 | N/A | Poulton et al., 2010 |
| MO2-tnfrsf18 | N/A | Poulton et al., 2010 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | TNF receptor superfamily member 18 | TNFR/NGFR cysteine-rich region | Tumour necrosis factor receptor 18 | Tumour necrosis factor receptor 18, N-terminal |
|---|---|---|---|---|---|---|
| UniProtKB:A9Y5K8 | InterPro | 259 | ||||
| UniProtKB:E7F804 | InterPro | 261 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnfrsf18-201
(1)
|
Ensembl | 1,540 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-20F24 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001113524 (1) | 896 nt | ||
| Genomic | GenBank:BX950172 (1) | 231139 nt | ||
| Polypeptide | UniProtKB:E7F804 (1) | 261 aa |
- Kasheta, M., Painter, C.A., Moore, F.E., Lobbardi, R., Bryll, A., Freiman, E., Stachura, D., Rogers, A.B., Houvras, Y., Langenau, D.M., Ceol, C.J. (2017) Identification and characterization of T reg-like cells in zebrafish. The Journal of experimental medicine. 214(12):3519-3530
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wiens, G.D., and Glenney, G.W. (2011) Origin and evolution of TNF and TNF receptor superfamilies. Developmental and comparative immunology. 35(12):1324-35
- Poulton, L.D., Nolan, K.F., Anastasaki, C., Waldmann, H., and Patton, E.E. (2010) A novel role for Glucocorticoid-Induced TNF Receptor Ligand (Gitrl) in early embryonic zebrafish development. The International journal of developmental biology. 54(5):815-825
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