ZFIN is now using GRCz12tu for Genomic Data
Gene

ppp2r2ba

ID
ZDB-GENE-101026-5
Name
protein phosphatase 2, regulatory subunit B, beta a
Symbol
ppp2r2ba Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Genome Assembly
GRCz12tu
Annotation Status
Current
Description
Predicted to enable protein phosphatase regulator activity. Predicted to be located in cytoskeleton and membrane. Predicted to be part of protein phosphatase type 2A complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; brain disease; breast cancer; and spinocerebellar ataxia type 12. Orthologous to human PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
No data available
Sequence Targeting Reagents
No data available
Human Disease
Associated With ppp2r2ba Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
spinocerebellar ataxia 12 Alliance Spinocerebellar ataxia 12 604326
1 - 1 of 1
Associated With ppp2r2ba Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018067 Protein phosphatase 2A regulatory subunit PR55, conserved site
Family IPR000009 Protein phosphatase 2A regulatory subunit PR55
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR036322 WD40-repeat-containing domain superfamily
Repeat IPR001680 WD40 repeat
1 - 5 of 5
Domain Details Per Protein
Protein Additional Resources Length Protein phosphatase 2A regulatory subunit PR55 Protein phosphatase 2A regulatory subunit PR55, conserved site WD40 repeat WD40-repeat-containing domain superfamily WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A0R4IJA2 InterPro 439
UniProtKB:A0A8M9PZZ4 InterPro 433
1 - 2 of 2
Transcripts
Genome Browsers
Genome Assembly: GRCz11Chromosome: 14
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ppp2r2ca-202 (1)
Ensembl
Ensembl 1,302 nt
ZFIN BLAST
mRNA ppp2r2ca-203 (1)
Ensembl
Ensembl 4,306 nt
ZFIN BLAST
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inFosmidCH1073-70E7ZFIN Curated Data
Contained inFosmidZFOS-882C7ZFIN Curated Data
1 - 2 of 2
Show
Sequences
Genome Browsers
Genome Assembly: GRCz12tuChromosome: 14
Type Accession # Genome Assembly Length (nt/aa) Analysis
RNARefSeq:XM_021481272 (1)GRCz12tu4449 nt
ZFIN BLASTNCBI BLASTEnsemblUCSC BLAT
GenomicGenBank:CU469526 (1)42306 nt
MegaBLASTEnsembl
PolypeptideUniProtKB:A0A0R4IJA2 (1)439 aa
ZFIN BLASTSIB BLASTEnsembl Protein Blast
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanPPP2R2B5
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MousePpp2r2b18
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
TSV
1 - 2 of 2
Show
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.