Gene

srpk3

ID
ZDB-GENE-101025-2
Name
SRSF protein kinase 3
Symbol
srpk3 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within cerebellum morphogenesis and skeletal myofibril assembly. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; heart tube; muscle; and retina. Orthologous to human SRPK3 (SRSF protein kinase 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Roychaudhury et al., 2024
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ck243aAllele with one deletionExon 3UnknownCRISPR
ck243bAllele with one deletionExon 3UnknownCRISPR
sa18907Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
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Human Disease
Associated With srpk3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Intellectual developmental disorder, X-linked 114 301134
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Associated With srpk3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Family IPR051334 Serine/Arginine-Rich Protein Kinases
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/Arginine-Rich Protein Kinases Serine/threonine-protein kinase, active site
UniProtKB:A0A8N7TFD0 InterPro 731
UniProtKB:A0A8M2BE87 InterPro 409
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 8
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA srpk3-201 (1) Ensembl 2,531 nt
mRNA srpk3-202 (1) Ensembl 822 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-109O5ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanSRPK3X
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseSrpk3X
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
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