Gene
arhgef6
- ID
- ZDB-GENE-101013-2
- Name
- Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
- Symbol
- arhgef6 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in lamellipodium assembly. Predicted to be located in cell projection. Predicted to be active in cytoplasm and lamellipodium. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Tay et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Calponin homology domain | CH domain superfamily | Dbl homology (DH) domain superfamily | Dbl homology domain | PH-like domain superfamily | Pleckstrin homology domain | RhoGEF 6/7, PH domain | Rho guanine nucleotide exchange factor 6/7, coiled-coil domain | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7F836 | InterPro | 766 | ||||||||||
| UniProtKB:A0A8M2BKJ3 | InterPro | 795 | ||||||||||
| UniProtKB:A0AB32T5Z9 | InterPro | 799 | ||||||||||
| UniProtKB:A0AB32T7S6 | InterPro | 770 | ||||||||||
| UniProtKB:A0AB32T9G7 | InterPro | 608 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arhgef6-201
(1)
|
Ensembl | 3,333 nt | ||
| mRNA |
arhgef6-202
(1)
|
Ensembl | 5,872 nt | ||
| mRNA |
arhgef6-203
(1)
|
Ensembl | 295 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-127L15 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005173222 (1) | 6021 nt | ||
| Genomic | GenBank:AL929434 (1) | 178948 nt | ||
| Polypeptide | UniProtKB:A0AB32T5Z9 (1) | 799 aa |
- Biswas, G., Kinoshita, S., Kono, T., Hikima, J.I., Sakai, M. (2015) Evolutionary evidence of tumor necrosis factor super family members in the Japanese pufferfish (Takifugu rubripes): Comprehensive genomic identification and expression analysis. Marine genomics. 22:25-36
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Giampietro, C., Deflorian, G., Gallo, S., Di Matteo, A., Pradella, D., Bonomi, S., Belloni, E., Nyqvist, D., Quaranta, V., Confalonieri, S., Bertalot, G., Orsenigo, F., Pisati, F., Ferrero, E., Biamonti, G., Fredrickx, E., Taveggia, C., Wyatt, C.D., Irimia, M., Di Fiore, P.P., Blencowe, B.J., Dejana, E., Ghigna, C. (2015) The alternative splicing factor Nova2 regulates vascular development and lumen formation. Nature communications. 6:84798479
- Dalton, L.E., Kamarashev, J., Ramirez, I.R., White, G., Malliri, A., and Hurlstone, A. (2013) Constitutive Rac Activation is not Sufficient to Initiate Melanocyte Neoplasia but Accelerates Malignant Progression. The Journal of investigative dermatology. 133(6):1572-81
- Tay, H.G., Ng, Y.W., and Manser, E. (2010) A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly. PLoS One. 5(4):e10125
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