Gene
kdm2ab
- ID
- ZDB-GENE-101007-5
- Name
- lysine (K)-specific demethylase 2Ab
- Symbol
- kdm2ab Nomenclature History
- Previous Names
-
- jhdm1A-a (1)
- unm_sa1479
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable histone demethylase activity and transcription coregulator activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human KDM2A (lysine demethylase 2A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa1479 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa28299 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa35681 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42387 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | F-box domain | JHDM1 Histone Demethylase | JmjC domain | Jumonji, helical domain | Leucine-rich repeat, cysteine-containing subtype | Leucine-rich repeat domain superfamily | Zinc finger, CXXC-type | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1PZC6 | InterPro | 1263 | ||||||||||||
| UniProtKB:E7F0J6 | InterPro | 1253 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kdm2ab-201
(1)
|
Ensembl | 7,078 nt | ||
| mRNA |
kdm2ab-202
(1)
|
Ensembl | 3,816 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-83D4 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001339761 (1) | 5475 nt | ||
| Genomic | GenBank:CT955967 (2) | 131798 nt | ||
| Polypeptide | UniProtKB:A0A8M1PZC6 (1) | 1263 aa |
- Comparative Orthology
- Alliance
- Fellous, A., Earley, R.L., Silvestre, F. (2018) The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction. Gene. 687:173-187
- Yu, S.H., Zhu, K.Y., Zhang, F., Wang, J., Yuan, H., Chen, Y., Jin, Y., Dong, M., Wang, L., Jia, X.E., Gao, L., Dong, Z.W., Ren, C.G., Chen, L.T., Huang, Q.H., Deng, M., Zon, L.I., Zhou, Y., Zhu, J., Xu, P.F., Liu, T.X. (2018) The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spi1 expression. Biochimica et biophysica acta. 1861(2):106-116
- Zhang, J., Zhou, Y., Wu, C., Wan, Y., Fang, C., Li, J., Fang, W., Yi, R., Zhu, G., Li, J., Wang, Y. (2018) Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts. Frontiers in endocrinology. 9:756
- Borgel, J., Tyl, M., Schiller, K., Pusztai, Z., Dooley, C.M., Deng, W., Wooding, C., White, R.J., Warnecke, T., Leonhardt, H., Busch-Nentwich, E.M., Bartke, T. (2017) KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1. Nucleic acids research. 45:1114-1129
- Scahill, C.M., Digby, Z., Sealy, I.M., Wojciechowska, S., White, R.J., Collins, J.E., Stemple, D.L., Bartke, T., Mathers, M.E., Patton, E.E., Busch-Nentwich, E.M. (2017) Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish. PLoS Genetics. 13:e1006959
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
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