Gene

tbcelb

ID

ZDB-GENE-100921-13

Name

tubulin folding cofactor E-like b

Symbol

tbcelb Nomenclature History

Previous Names

tbcel (1)
si:ch73-37h15.1 (1)

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable alpha-tubulin binding activity. Predicted to be involved in microtubule cytoskeleton organization; post-chaperonin tubulin folding pathway; and tubulin complex assembly. Predicted to act upstream of or within protein folding. Predicted to be active in cytoplasm. Orthologous to human TBCEL (tubulin folding cofactor E like).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa2191	Allele with one point mutation	Unknown	Premature Stop	ENU
sa33745	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With tbcelb Human Ortholog

No data available

Associated With tbcelb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000626	Ubiquitin-like domain
Domain	IPR047991	Tubulin-specific chaperone cofactor E-like protein, ubiquitin-like domain
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily

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Domain Details Per Protein

Protein	Additional Resources	Length	Leucine-rich repeat domain superfamily	Tubulin-specific chaperone cofactor E-like protein, ubiquitin-like domain	Ubiquitin-like domain	Ubiquitin-like domain superfamily
UniProtKB:E9QCV6	InterPro	428

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Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 5

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	tbcelb-201 (1) Ensembl	Ensembl		1,455 nt	Select Tool ZFIN BLAST
mRNA	tbcelb-202 (1) Ensembl	Ensembl		1,752 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH73-37H15	CU856356	ZFIN Curated Data
Contained in	BAC	CH211-122G23	CR339044	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_002662169 (1)	2091 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR339044 (1)	177385 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:E9QCV6 (1)	428 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	TBCEL	11	Ensembl:ENSG00000154114 Gene:219899 HGNC:28115 OMIM:610451	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)
Mouse	Tbcel	9	Ensembl:ENSMUSG00000037287 Gene:272589 MGI:1925543	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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