Gene
myh14
- ID
- ZDB-GENE-100921-1
- Name
- myosin, heavy chain 14, non-muscle
- Symbol
- myh14 Nomenclature History
- Previous Names
-
- si:ch211-120k19.2
- si:ch211-120k19.3
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actomyosin structure organization; mitotic cytokinesis; and regulation of cell shape. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in heart; immature eye; nervous system; otic vesicle; and spinal cord neural tube. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 4A and sensorineural hearing loss. Orthologous to human MYH14 (myosin heavy chain 14).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Huang et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa15579 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa16888 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17178 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22798 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa36084 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa36085 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44846 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa45571 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 8 of 8
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-myh14 | Lin et al., 2025 | |
| CRISPR2-myh14 | Lin et al., 2025 | |
| CRISPR3-myh14 | Lin et al., 2025 |
1 - 3 of 3
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 4A | Alliance | Deafness, autosomal dominant 4A | 600652 |
| ?Peripheral neuropathy, myopathy, hoarseness, and hearing loss | 614369 |
1 - 2 of 2
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin head, motor domain-like | Myosin, N-terminal, SH3-like | Myosin S1 fragment, N-terminal | Myosin tail | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AQG4 | InterPro | 2065 | |||||||
| UniProtKB:A0A8M3AJ07 | InterPro | 2049 | |||||||
| UniProtKB:A0A8M3B1K3 | InterPro | 2056 | |||||||
| UniProtKB:A0A8M3AHY4 | InterPro | 2061 | |||||||
| UniProtKB:A0A8M2B482 | InterPro | 2060 |
1 - 5 of 9 Show all
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-120K19 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068214105 (1) | 12901 nt | ||
| Genomic | GenBank:AL929505 (1) | 178839 nt | ||
| Polypeptide | UniProtKB:A0A8M3AQG4 (1) | 2065 aa |
- Comparative Orthology
- Alliance
- Lin, S.J., Huang, K., Petree, C., Qin, W., Varshney, P., Varshney, G.K. (2025) Optimizing gRNA selection for high-penetrance F0 CRISPR screening for interrogating disease gene function. Nucleic acids research. 53:
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, Y., Wang, X., Wang, X., Xu, M., Liu, M., and Liu, D. (2013) Nonmuscle myosin II-B (myh10) expression analysis during zebrafish embryonic development. Gene expression patterns : GEP. 13(7):265-270
1 - 5 of 5
Show