Gene

kif1aa

ID

ZDB-GENE-100913-3

Name

kinesin family member 1Aa

Symbol

kif1aa Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have ATP-dependent microtubule motor activity, plus-end-directed and microtubule binding activity. Predicted to be involved in cytoskeleton-dependent intracellular transport; microtubule-based movement; and vesicle-mediated transport. Predicted to localize to axon; dendrite; and microtubule cytoskeleton. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 9; hereditary sensory neuropathy; hereditary sensory neuropathy type 2C; hereditary spastic paraplegia; and hereditary spastic paraplegia 30. Orthologous to human KIF1A (kinesin family member 1A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kif1aa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hereditary sensory neuropathy type 2C	Alliance	Neuropathy, hereditary sensory, type IIC	614213
hereditary spastic paraplegia 30	Alliance	Spastic paraplegia 30, autosomal dominant	610357
hereditary spastic paraplegia 30	Alliance	Spastic paraplegia 30, autosomal recessive	610357
NESCAV syndrome	Alliance	NESCAV syndrome	614255

Associated With kif1aa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019821	Kinesin motor domain, conserved site
Domain	IPR000253	Forkhead-associated (FHA) domain
Domain	IPR001752	Kinesin motor domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR022140	Kinesin-like KIF1-type
Domain	IPR022164	Kinesin-like
Domain	IPR032405	Kinesin-associated
Family	IPR027640	Kinesin-like protein
Homologous_superfamily	IPR008984	SMAD/FHA domain superfamily
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily

Domain Details Per Protein

Protein	Length	Forkhead-associated (FHA) domain	Kinesin-associated	Kinesin-like	Kinesin-like KIF1-type	Kinesin-like protein	Kinesin motor domain	Kinesin motor domain, conserved site	Kinesin motor domain superfamily	PH-like domain superfamily	Pleckstrin homology domain	P-loop containing nucleoside triphosphate hydrolase	SMAD/FHA domain superfamily
UniProtKB:E7F4K4 InterPro	1678
UniProtKB:X1WHC0 InterPro	1681

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Length (nt)	Analysis
mRNA	kif1aa-202 (1) Ensembl	9247 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations