Gene
maml1
- ID
- ZDB-GENE-100820-2
- Name
- mastermind-like transcriptional coactivator 1
- Symbol
- maml1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription of Notch receptor target. Predicted to act upstream of or within Notch signaling pathway and positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be active in nucleoplasm. Is expressed in telencephalon. Orthologous to human MAML1 (mastermind like transcriptional coactivator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Chapouton et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa10050 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11346 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16266 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16401 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22440 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR019082 | Neurogenic mastermind-like, N-terminal |
| Domain | IPR048455 | Mastermind-like 1/3, transactivation domain 2 |
| Domain | IPR048456 | Mastermind-like 1/3, transactivation domain 1 |
| Family | IPR046369 | Mastermind-like 1-3 |
| Homologous_superfamily | IPR046370 | Neurogenic mastermind-like, N-terminal domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Mastermind-like 1-3 | Mastermind-like 1/3, transactivation domain 1 | Mastermind-like 1/3, transactivation domain 2 | Neurogenic mastermind-like, N-terminal | Neurogenic mastermind-like, N-terminal domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IKI2 | InterPro | 1049 | |||||
| UniProtKB:A0A8N7TF91 | InterPro | 1048 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-121B13 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_690627 (1) | 6533 nt | ||
| Genomic | GenBank:BX530081 (1) | 162058 nt | ||
| Polypeptide | UniProtKB:A0A0R4IKI2 (1) | 1049 aa |
- Comparative Orthology
- Alliance
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Hung, I.C., Cherng, B.W., Hsu, W.M., and Lee, S.J. (2013) Calnexin is required for zebrafish posterior lateral line development. The International journal of developmental biology. 57(5):427-438
- Chapouton, P., Skupien, P., Hesl, B., Coolen, M., Moore, J.C., Madelaine, R., Kremmer, E., Faus-Kessler, T., Blader, P., Lawson, N.D., and Bally-Cuif, L. (2010) Notch activity levels control the balance between quiescence and recruitment of adult neural stem cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(23):7961-7974
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