Gene
adcy1b
- ID
- ZDB-GENE-100805-1
- Name
- adenylate cyclase 1b
- Symbol
- adcy1b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable adenylate cyclase activity. Acts upstream of or within axon midline choice point recognition; retinal ganglion cell axon guidance; and sensory perception of sound. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 44. Orthologous to human ADCY1 (adenylate cyclase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Santos-Cortez et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-adcy1b | N/A | (2) |
| MO2-adcy1b | N/A | Xu et al., 2010 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 44 | Alliance | ?Deafness, autosomal recessive 44 | 610154 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018297 | Adenylyl cyclase class-4/guanylyl cyclase, conserved site |
| Domain | IPR001054 | Adenylyl cyclase class-3/4/guanylyl cyclase |
| Domain | IPR009398 | Adenylate cyclase, conserved domain |
| Domain | IPR032628 | Adenylate cyclase, N-terminal |
| Family | IPR030672 | Adenylate cyclase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Adenylate cyclase | Adenylate cyclase, conserved domain | Adenylate cyclase, N-terminal | Adenylyl cyclase class-3/4/guanylyl cyclase | Adenylyl cyclase class-4/guanylyl cyclase, conserved site | Nucleotide cyclase |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:D1MIA3 | InterPro | 1114 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adcy1b-201
(1)
|
Ensembl | 2,532 nt | ||
| mRNA |
adcy1b-202
(1)
|
Ensembl | 1,547 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-443F24 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001168350 (1) | 3385 nt | ||
| Genomic | GenBank:LO018378 (1) | 34468 nt | ||
| Polypeptide | UniProtKB:D1MIA3 (1) | 1114 aa |
- Yang, S., Zhang, X., Li, X., Yin, X., Teng, L., Ji, G., Li, H. (2022) Evolutionary and Expression Analysis of MOV10 and MOV10L1 Reveals Their Origin, Duplication and Divergence. International Journal of Molecular Sciences. 23(14):
- Lissouba, A., Liao, M., Kabashi, E., Drapeau, P. (2018) Transcriptomic Analysis of Zebrafish TDP-43 Transgenic Lines. Frontiers in molecular neuroscience. 11:463
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Zhong, Y., Duan, C. (2017) Lamprey IGF-Binding Protein-3 Has IGF-Dependent and -Independent Actions. Frontiers in endocrinology. 7:174
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Santos-Cortez, R.L., Lee, K., Giese, A.P., Ansar, M., Amin-Ud-Din, M., Rehn, K., Wang, X., Aziz, A., Chiu, I., Hussain Ali, R., Smith, J.D., Shendure, J., Bamshad, M., Nickerson, D.A., Ahmed, Z.M., Ahmad, W., Riazuddin, S., and Leal, S.M. (2014) Adenylate cyclase 1 (ADCY1) mutations cause recessive hearing impairment in humans and defects in hair cell function and hearing in zebrafish. Human molecular genetics. 23(12):3289-98
- Xu, H., Leinwand, S.G., Dell, A.L., Fried-Cassorla, E., and Raper, J.A. (2010) The Calmodulin-Stimulated Adenylate Cyclase ADCY8 Sets the Sensitivity of Zebrafish Retinal Axons to Midline Repellents and Is Required for Normal Midline Crossing. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(21):7423-7433
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