Gene
mrap2a
- ID
- ZDB-GENE-100729-3
- Name
- melanocortin 2 receptor accessory protein 2a
- Symbol
- mrap2a Nomenclature History
- Previous Names
-
- si:ch211-198c19.4
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables type 4 melanocortin receptor binding activity. Involved in energy homeostasis and energy reserve metabolic process. Acts upstream of or within several processes, including negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; protein localization to cell surface; and regulation of growth. Located in Golgi apparatus; endoplasmic reticulum; and plasma membrane. Is expressed in several structures, including adipose tissue; diencephalon; heart; liver; and pleuroperitoneal region. Orthologous to human MRAP2 (melanocortin 2 receptor accessory protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Sebag et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {?Obesity, susceptibility to, BMIQ18} | 615457 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR028111 | Melanocortin-2 receptor accessory protein family |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Melanocortin-2 receptor accessory protein family |
|---|---|---|---|
| UniProtKB:F8W4H9 | InterPro | 217 | |
| UniProtKB:A0AB13ABH2 | InterPro | 217 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mrap2a-202
(1)
|
Ensembl | 1,950 nt | ||
| ncRNA |
mrap2a-001
(1)
|
Ensembl | 481 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-198C19 | ||
| Contained in | BAC | CH211-214D1 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001424034 (1) | 1592 nt | ||
| Genomic | GenBank:AL954130 (1) | 235236 nt | ||
| Polypeptide | UniProtKB:A0AB13ABH2 (1) | 217 aa |
- Fullone, M.R., Maftei, D., Vincenzi, M., Lattanzi, R., Miele, R. (2024) MRAP2a Binds and Modulates Activity and Localisation of Prokineticin Receptor 1 in Zebrafish. International Journal of Molecular Sciences. 25(14):
- Navarro, S., Crespo, D., Schulz, R.W., Ge, W., Rotllant, J., Cerdá-Reverter, J.M., Rocha, A. (2022) Role of the Melanocortin System in Gonadal Steroidogenesis of Zebrafish. Animals : an open access journal from MDPI. 12(20):
- Xu, J., Wang, M., Fu, Y., Zhang, C., Kuang, Z., Bian, S., Wan, R., Qu, S., Zhang, C. (2022) Reversion of MRAP2 Protein Sequence Generates a Functional Novel Pharmacological Modulator for MC4R Signaling. Biology. 11(6)
- Wang, M., Zhai, Y., Lu, L., Zhang, C., Li, N., Xue, S., Cheng, D., Fu, S., Liu, Q., Zhang, C. (2021) Elucidation of the dimeric interplay of dual MRAP2 proteins in the zebrafish. Journal of Cellular Physiology. 236(9):6472-6480
- Vera-Chang, M.N., Moon, T.W., Trudeau, V.L. (2019) Cortisol disruption and transgenerational alterations in the expression of stress-related genes in zebrafish larvae following fluoxetine exposure. Toxicology and applied pharmacology. 382:114742
- Wang, M., Chen, Y., Zhu, M., Xu, B., Guo, W., Lyu, Y., Zhang, C. (2019) Pharmacological modulation of melanocortin-4 receptor by melanocortin receptor accessory protein 2 in Nile tilapia. General and comparative endocrinology. 282:113219
- Zhu, M., Wang, M., Chen, Y., Zhang, C. (2019) Pharmacological modulation of two melanocortin-5 receptors by MRAP2 proteins in zebrafish. Journal of molecular endocrinology.
- Zhu, M., Xu, B., Wang, M., Liu, S., Zhang, Y., Zhang, C. (2019) Pharmacological modulation of MRAP2 protein on melanocortin receptors in the sea lamprey. Endocrine connections. 8:378-388
- Cortés, R., Teles, M., Oliveira, M., Fierro-Castro, C., Tort, L., Cerdá-Reverter, J.M. (2017) Effects of acute handling stress on short-term central expression of orexigenic/anorexigenic genes in zebrafish. Fish physiology and biochemistry. 44(1):257-272
- Liang, L., Schmid, K., Sandhu, N., Angleson, J.K., Vijayan, M.M., Dores, R.M. (2015) Structure/function studies on the activation of the rainbow trout melanocortin-2 receptor. General and comparative endocrinology. 210:145-51
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