Gene
gpr137ba
- ID
- ZDB-GENE-100721-1
- Name
- G protein-coupled receptor 137Ba
- Symbol
- gpr137ba Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Involved in negative regulation of bone resorption; negative regulation of osteoclast differentiation; and regulation of autophagy. Acts upstream of or within bone remodeling and regulation of lysosome size. Predicted to be located in lysosome and membrane. Predicted to be active in lysosomal membrane. Is expressed in female organism. Orthologous to human GPR137B (G protein-coupled receptor 137B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Newman et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR029723 | Integral membrane protein GPR137 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Integral membrane protein GPR137 |
|---|---|---|---|
| UniProtKB:E7F594 | InterPro | ||
| UniProtKB:A0AB13A9K2 | InterPro | 373 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gpr137ba-201
(1)
|
Ensembl | 4,733 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001424033 (1) | 1537 nt | ||
| Genomic | GenBank:CU929100 (1) | 110276 nt | ||
| Polypeptide | UniProtKB:A0AB13A9K2 (1) | 373 aa |
- Gan, L., Seki, A., Shen, K., Iyer, H., Han, K., Hayer, A., Wollman, R., Ge, X., Lin, J.R., Dey, G., Talbot, W.S., Meyer, T. (2019) The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity. Nature cell biology. 21(5):614-626
- Newman, M., Hin, N., Pederson, S., Lardelli, M. (2019) Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular brain. 12:43
- Urso, K., Caetano-Lopes, J., Lee, P.Y., Yan, J., Henke, K., Sury, M., Liu, H., Zgoda, M., Jacome-Galarza, C., Nigrovic, P.A., Duryea, J., Harris, M.P., Charles, J.F. (2019) A role for G protein-coupled receptor 137b in bone remodeling in mouse and zebrafish. Bone. 127:104-113
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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