Gene

dock3

ID

ZDB-GENE-100624-1

Name

dedicator of cytokinesis 3

Symbol

dock3 Nomenclature History

Previous Names

si:ch211-216d10.1

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have GTPase activator activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in small GTPase mediated signal transduction. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human DOCK3 (dedicator of cytokinesis 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dock3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with impaired intellectual development, hypotonia, and ataxia	618292

Associated With dock3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001452	SH3 domain
Domain	IPR026800	Dedicator of cytokinesis protein 3, DHR2 domain
Domain	IPR027007	C2 DOCK-type domain
Domain	IPR027357	DOCKER domain
Domain	IPR032376	Dedicator of cytokinesis, N-terminal domain
Domain	IPR037811	Dedicator of cytokinesis B, C2 domain
Domain	IPR046769	DOCKER, Lobe A
Domain	IPR046770	DOCKER, Lobe B
Domain	IPR046773	DOCKER, Lobe C
Family	IPR026791	Dedicator of cytokinesis
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR042455	Dedicator of cytokinesis, N-terminal, subdomain 1
Homologous_superfamily	IPR043161	Dedicator of cytokinesis, C-terminal, lobe A
Homologous_superfamily	IPR043162	Dedicator of cytokinesis, C-terminal, lobe C

Domain Details Per Protein

Protein	Length	Armadillo-type fold	C2 DOCK-type domain	C2 domain superfamily	Dedicator of cytokinesis	Dedicator of cytokinesis B, C2 domain	Dedicator of cytokinesis, C-terminal, lobe A	Dedicator of cytokinesis, C-terminal, lobe C	Dedicator of cytokinesis, N-terminal domain	Dedicator of cytokinesis, N-terminal, subdomain 1	Dedicator of cytokinesis protein 3, DHR2 domain	DOCKER domain	DOCKER, Lobe A	DOCKER, Lobe B	DOCKER, Lobe C	SH3 domain	SH3-like domain superfamily
UniProtKB:A0A8M9P4T5 InterPro	1906
UniProtKB:A0A8M3AXY0 InterPro	2070
UniProtKB:A0A8M6Z3K1 InterPro	2068
UniProtKB:A0A8M9PSK3 InterPro	1924
UniProtKB:A0A8M6YXG5 InterPro	2108
UniProtKB:A0A8M3B5S0 InterPro	2094
UniProtKB:A0A8M3AMH0 InterPro	2101
UniProtKB:A0A8M6YVP8 InterPro	2069
UniProtKB:A0A8M6YV41 InterPro	2077
UniProtKB:A0A8M3AN91 InterPro	2087
UniProtKB:A0A8M3AXX4 InterPro	1990
UniProtKB:A0A8M6Z4A0 InterPro	2099
UniProtKB:A0A8M3AUX0 InterPro	2107

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dock3-204 (1) Ensembl	Havana	5155 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	dock3-205 (1) Ensembl	Havana	726 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	dock3-003 (1) Ensembl	Havana	683 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	dock3-004 (1) Ensembl	Havana	539 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations