Gene
ttbk1b
- ID
- ZDB-GENE-100609-5
- Name
- tau tubulin kinase 1b
- Symbol
- ttbk1b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in microtubule cytoskeleton. Predicted to be active in cytoplasm and nucleus. Orthologous to human TTBK1 (tau tubulin kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6470 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa9312 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23059 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36393 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36394 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45601 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa45602 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR042714 | Tau-tubulin kinase 1, catalytic domain |
| Family | IPR050235 | Casein Kinase 1 Ser/Thr Protein Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Casein Kinase 1 Ser/Thr Protein Kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Tau-tubulin kinase 1, catalytic domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q6H3 | InterPro | 733 | |||||
| UniProtKB:A0A8M9PVD4 | InterPro | 1219 | |||||
| UniProtKB:X1WBG3 | InterPro | 1219 | |||||
| UniProtKB:A0A8M6Z1Q9 | InterPro | 733 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ttbk1b-201
(1)
|
Ensembl | 2,016 nt | ||
| mRNA |
ttbk1b-202
(1)
|
Ensembl | 824 nt | ||
| mRNA |
ttbk1b-203
(1)
|
Ensembl | 4,811 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-183F23 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-69P10 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021473129 (1) | 7739 nt | ||
| Genomic | GenBank:BX005258 (1) | 193078 nt | ||
| Polypeptide | UniProtKB:A0A8M9PVD4 (1) | 1219 aa |
- Dragojević, J., Mihaljević, I., Popović, M., Zaja, R., Smital, T. (2018) In vitro characterization of zebrafish (Danio rerio) organic anion transporters Oat2a-e. Toxicology in vitro : an international journal published in association with BIBRA. 46:246-256
- Mihaljevic, I., Popovic, M., Zaja, R., Smital, T. (2016) Phylogenetic, syntenic, and tissue expression analysis of slc22 genes in zebrafish (Danio rerio). BMC Genomics. 17:626
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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