Gene

inpp5kb

ID
ZDB-GENE-100408-3
Name
inositol polyphosphate-5-phosphatase Kb
Symbol
inpp5kb Nomenclature History
Previous Names
  • inpp5k
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to enable phosphatase activity. Acts upstream of or within camera-type eye development and skeletal muscle fiber development. Predicted to be active in several cellular components, including endoplasmic reticulum; neuron projection; and ruffle. Is expressed in brain; head; muscle; post-vent region; and visual system. Human ortholog(s) of this gene implicated in congenital muscular dystrophy with cataracts and intellectual disability. Orthologous to human INPP5K (inositol polyphosphate-5-phosphatase K).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
No data available
Sequence Targeting Reagents
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Human Disease
Associated With inpp5kb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital muscular dystrophy with cataracts and intellectual disability Alliance Muscular dystrophy, congenital, with cataracts and intellectual disability 617404
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Associated With inpp5kb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000300 Inositol polyphosphate-related phosphatase
Domain IPR041611 SKICH domain
Family IPR046985 Inositol 5-phosphatase
Homologous_superfamily IPR036691 Endonuclease/exonuclease/phosphatase superfamily
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Domain Details Per Protein
Protein Additional Resources Length Endonuclease/exonuclease/phosphatase superfamily Inositol 5-phosphatase Inositol polyphosphate-related phosphatase SKICH domain
UniProtKB:A0A8M2B261 InterPro 526
UniProtKB:A0A8M2B205 InterPro 517
UniProtKB:A0A8N7UTA0 InterPro 468
UniProtKB:A0A8M9QL16 InterPro 517
UniProtKB:A0A2R8QKI3 InterPro 526
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 10
Type Name Annotation Method Has Havana Data Length (nt) Analysis
antisense ottdart00000059909 (1) Ensembl 953 nt
mRNA inpp5kb-201 (1) Ensembl 3,508 nt
mRNA inpp5kb-202 (1) Ensembl 1,467 nt
mRNA inpp5kb-203 (1) Ensembl 3,682 nt
mRNA inpp5kb-204 (1) Ensembl 3,535 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-280O12ZFIN Curated Data
Contained inBACCH211-213E17ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanINPP5K17
Conserved genome location (synteny) (1)
Amino acid sequence comparison (4)
MouseInpp5k11
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
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