Gene
nlgn4xa
- ID
- ZDB-GENE-100309-2
- Name
- neuroligin 4 X-linked a
- Symbol
- nlgn4xa Nomenclature History
- Previous Names
-
- nlgn4a
- nlgn4b (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable neurexin family protein binding activity. Predicted to be involved in synapse assembly. Predicted to act upstream of or within cell adhesion. Predicted to be located in membrane. Predicted to be active in postsynaptic specialization membrane. Is expressed in several structures, including brain; eye; gonad; spinal cord interneuron; and swim bladder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to several human genes including NLGN4X (neuroligin 4 X-linked).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa18031 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32702 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32703 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32704 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39634 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zko618a | Allele with one deletion | Unknown | Unknown | CRISPR | |
| zko618b | Allele with one delins | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha/Beta hydrolase fold | Carboxylesterase, type B | Carboxylesterase type B, conserved site | Neuroligin | Neuroligin and Bile salt-activated lipase |
|---|---|---|---|---|---|---|---|
| UniProtKB:R4GE10 | InterPro | 826 | |||||
| UniProtKB:A0A8M9QBU0 | InterPro | 844 | |||||
| UniProtKB:D0EVX4 | InterPro | 826 | |||||
| UniProtKB:A0AB32TRR4 | InterPro | 843 |
1 - 4 of 4
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nlgn4xa-201
(1)
|
Ensembl | 5,478 nt | ||
| mRNA |
nlgn4xa-202
(1)
|
Ensembl | 2,532 nt | ||
| mRNA |
nlgn4xa-203
(1)
|
Ensembl | 4,719 nt |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available
No data available