Gene
mmp21
- ID
- ZDB-GENE-100226-2
- Name
- matrix metallopeptidase 21
- Symbol
- mmp21 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have metalloendopeptidase activity. Involved in determination of heart left/right asymmetry. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in visceral heterotaxy. Is expressed in Kupffer's vesicle. Orthologous to human MMP21 (matrix metallopeptidase 21).
- Genome Resources
- Note
-
XM_001342685 in ZDB-PUB-110131-35
- Comparative Information
-
- All Expression Data
- 2 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Heterotaxy, visceral, 7, autosomal | 616749 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001818 | Peptidase M10, metallopeptidase |
| Domain | IPR002477 | Peptidoglycan binding-like |
| Domain | IPR006026 | Peptidase, metallopeptidase |
| Domain | IPR033739 | Peptidase M10A, catalytic domain |
| Family | IPR021190 | Peptidase M10A |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR036365 | PGBD-like superfamily |
| Homologous_superfamily | IPR036375 | Hemopexin-like domain superfamily |
| Repeat | IPR018487 | Hemopexin-like repeats |
Domain Details Per Protein
| Protein | Length | Hemopexin-like domain superfamily | Hemopexin-like repeats | Metallopeptidase, catalytic domain superfamily | Peptidase M10A | Peptidase M10A, catalytic domain | Peptidase M10, metallopeptidase | Peptidase, metallopeptidase | Peptidoglycan binding-like | PGBD-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0N9E2K8
|
599 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids