Gene
gdf2
- ID
- ZDB-GENE-100107-1
- Name
- growth differentiation factor 2
- Symbol
- gdf2 Nomenclature History
- Previous Names
-
- bmp9 (2)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Involved in angiogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in hereditary hemorrhagic telangiectasia. Orthologous to human GDF2 (growth differentiation factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Capasso et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-gdf2 | N/A | (2) |
| MO2-gdf2 | N/A | Laux et al., 2013 |
| TALEN1-gdf2 | (3) |
1 - 3 of 3
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary hemorrhagic telangiectasia | Alliance | Telangiectasia, hereditary hemorrhagic, type 5 | 615506 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017948 | Transforming growth factor beta, conserved site |
| Domain | IPR001111 | TGF-beta, propeptide |
| Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
| Family | IPR015615 | Transforming growth factor-beta-related |
| Homologous_superfamily | IPR029034 | Cystine-knot cytokine |
1 - 5 of 5
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | TGF-beta, propeptide | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-related |
|---|---|---|---|---|---|---|---|
| UniProtKB:F1QWZ4 | InterPro | 389 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-77E10 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001171586 (1) | 1170 nt | ||
| Genomic | GenBank:CR450691 (1) | 157371 nt | ||
| Polypeptide | UniProtKB:F1QWZ4 (1) | 389 aa |
- Li, Y., Shang, Q., Li, P., Yang, Z., Yang, J., Shi, J., Ge, S., Wang, Y., Fan, X., Jia, R. (2020) BMP9 attenuates occurrence of venous malformation by maintaining endothelial quiescence and strengthening vessel walls via SMAD1/5/ID1/α-SMA pathway. Journal of Molecular and Cellular Cardiology. 147:92-107
- Capasso, T.L., Li, B., Volek, H.J., Khalid, W., Rochon, E.R., Anbalagan, A., Herdman, C., Yost, H.J., Villanueva, F.S., Kim, K., Roman, B.L. (2019) BMP10-mediated ALK1 signaling is continuously required for vascular development and maintenance. Angiogenesis. 23(2):203-220
- Chen, L., Dong, C., Kong, S., Zhang, J., Li, X., Xu, P. (2017) Genome wide identification, phylogeny, and expression of bone morphogenetic protein genes in tetraploidized common carp (Cyprinus carpio). Gene. 627:157-163
- Tzung, K.W., Goto, R., Saju, J.M., Sreenivasan, R., Saito, T., Arai, K., Yamaha, E., Hossain, M.S., Calvert, M.E., Orbán, L. (2015) Early Depletion of Primordial Germ Cells in Zebrafish Promotes Testis Formation. Stem Cell Reports. 4(1):61-73
- Laux, D.W., Young, S., Donovan, J.P., Mansfield, C.J., Upton, P.D., and Roman, B.L. (2013) Circulating Bmp10 acts through endothelial Alk1 to mediate flow-dependent arterial quiescence. Development (Cambridge, England). 140(16):3403-12
- Wooderchak-Donahue, W.L., McDonald, J., O'Fallon, B., Upton, P.D., Li, W., Roman, B.L., Young, S., Plant, P., Fülöp, G.T., Langa, C., Morrell, N.W., Botella, L.M., Bernabeu, C., Stevenson, D.A., Runo, J.R., and Bayrak-Toydemir, P. (2013) BMP9 Mutations Cause a Vascular-Anomaly Syndrome with Phenotypic Overlap with Hereditary Hemorrhagic Telangiectasia. American journal of human genetics. 93(3):530-7
- Bland, R.J. (2001) Isolation, characterisation and evolution of zebrafish (Danio rerio) bmp9, bmp10 and gdf11. Ph.D. Thesis. :240p
1 - 7 of 7
Show