Gene
kcnt1a
- ID
- ZDB-GENE-091231-1
- Name
- potassium sodium-activated channel subfamily T member 1a
- Symbol
- kcnt1a Nomenclature History
- Previous Names
-
- kcnt1
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable intracellular sodium-activated potassium channel activity and outward rectifier potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport and potassium ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in midbrain; olfactory placode; peripheral olfactory organ; and tegmentum. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 5 and developmental and epileptic encephalopathy 14. Orthologous to human KCNT1 (potassium sodium-activated channel subfamily T member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Silic et al., 2021
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa12911 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23851 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa29503 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa43577 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nocturnal frontal lobe epilepsy 5 | Alliance | Epilepsy nocturnal frontal lobe, 5 | 615005 |
| developmental and epileptic encephalopathy 14 | Alliance | Developmental and epileptic encephalopathy 14 | 614959 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Calcium-activated potassium channel BK, alpha subunit | Calcium-activated potassium channel slowpoke-like | NAD(P)-binding domain superfamily | Potassium channel domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3ALW9 | InterPro | 1173 | ||||
| UniProtKB:A0A8M3AWL0 | InterPro | 1172 | ||||
| UniProtKB:A0A8M3ATL3 | InterPro | 1159 | ||||
| UniProtKB:A0AB32TBQ1 | InterPro | 1230 | ||||
| UniProtKB:A0AB32TBZ7 | InterPro | 1217 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcnt1-206
(1)
|
Ensembl | 3,264 nt | ||
| mRNA |
kcnt1a-201
(1)
|
Ensembl | 3,169 nt | ||
| mRNA |
kcnt1a-202
(1)
|
Ensembl | 3,378 nt | ||
| mRNA |
kcnt1a-203
(1)
|
Ensembl | 3,360 nt | ||
| mRNA |
kcnt1a-204
(1)
|
Ensembl | 3,111 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-286L20 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068215964 (1) | 7979 nt | ||
| Genomic | GenBank:CU694955 (2) | 94664 nt | ||
| Polypeptide | UniProtKB:A0AB32TFH9 (1) | 1231 aa |
- Silic, M.R., Black, M.M., Zhang, G. (2021) Phylogenetic and developmental analyses indicate complex functions of Calcium-Activated Potassium Channels in zebrafish embryonic development. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(10):1477-1493
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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