Gene
dlec1
- ID
- ZDB-GENE-091204-65
- Name
- DLEC1 cilia and flagella associated protein
- Symbol
- dlec1 Nomenclature History
- Previous Names
-
- si:dkey-246l21.2
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable tubulin binding activity. Predicted to be located in cell projection. Predicted to be active in cilium and cytoplasm. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human DLEC1 (DLEC1 cilia and flagella associated protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Choksi et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa8863 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa15793 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa16256 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18315 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24479 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37869 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa44120 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Deleted in lung and esophageal cancer protein 1 | HYDIN/VesB/CFA65-like, Ig-like domain | Immunoglobulin-like fold |
|---|---|---|---|---|---|
| UniProtKB:A0A8M6YWD1 | InterPro | 1701 | |||
| UniProtKB:A0A8N7UUL3 | InterPro | 1702 | |||
| UniProtKB:E9QEP3 | InterPro | 1701 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-225E5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-246L21 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_017353955 (1) | |||
| Genomic | GenBank:CR388015 (1) | 140648 nt | ||
| Polypeptide | UniProtKB:A0A8N7UUL3 (1) | 1702 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Choksi, S.P., Babu, D., Lau, D., Yu, X., Roy, S. (2014) Systematic discovery of novel ciliary genes through functional genomics in the zebrafish. Development (Cambridge, England). 141:3410-9
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