Gene
rbfox3b
- ID
- ZDB-GENE-091204-46
- Name
- RNA binding fox-1 homolog 3b
- Symbol
- rbfox3b Nomenclature History
- Previous Names
-
- rbfox3l
- si:ch73-322f21.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable mRNA binding activity. Predicted to be involved in nervous system development and regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Is expressed in brain and spinal cord. Orthologous to human RBFOX3 (RNA binding fox-1 homolog 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la024396Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa33097 | Allele with one point mutation | Unknown | Unknown | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Fox-1 C-terminal domain | FOX1, RNA recognition motif | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA binding protein fox-1 homolog 1-3 | RNA binding protein fox-1 homolog 1-like | RNA recognition motif domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PBK7 | InterPro | 334 | |||||||
| UniProtKB:A0A8M9PBK2 | InterPro | 359 | |||||||
| UniProtKB:A0A8M9PN39 | InterPro | 356 | |||||||
| UniProtKB:A0A8M9Q1D6 | InterPro | 345 | |||||||
| UniProtKB:A0A8M9PBL0 | InterPro | 328 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rbfox3b-201
(1)
|
Ensembl | 912 nt | ||
| mRNA |
rbfox3b-202
(1)
|
Ensembl | 1,254 nt | ||
| mRNA |
rbfox3b-204
(1)
|
Ensembl | 861 nt | ||
| mRNA |
rbfox3b-205
(1)
|
Ensembl | 1,311 nt | ||
| mRNA |
rbfox3b-206
(1)
|
Ensembl | 819 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-201A22 | ZFIN Curated Data | |
| Contained in | BAC | CH73-322F21 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-171J23 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-387M17 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068218656 (1) | 4548 nt | ||
| Genomic | GenBank:FP243381 (1) | 78713 nt | ||
| Polypeptide | UniProtKB:A0A8M9PBK2 (1) | 359 aa |
- Antón-Galindo, E., Adel, M.R., García-González, J., Leggieri, A., López-Blanch, L., Irimia, M., Norton, W.H.J., Brennan, C.H., Fernàndez-Castillo, N., Cormand, B. (2024) Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in two zebrafish models. Translational psychiatry. 14:9999
- Zhang, T., Alonzo, I., Stubben, C., Geng, Y., Herdman, C., Chandler, N., Doane, K.P., Pluimer, B.R., Trauger, S.A., Peterson, R.T. (2023) A zebrafish model of Combined Saposin Deficiency identifies acid sphingomyelinase as a potential therapeutic target. Disease models & mechanisms. 16(7):
- Won, M., Lee, S., Choi, S., Ro, H., Kim, K.J., Kim, J.H., Kim, K.E., Kim, K.K. (2016) Identification and characterization of the RNA-binding protein Rbfox3 in zebrafish embryo. Biochemical and Biophysical Research Communications. 472(2):373-8
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Gallagher, T.L., Arribere, J.A., Geurts, P.A., Exner, C.R., McDonald, K.L., Dill, K.K., Marr, H.L., Adkar, S.S., Garnett, A.T., Amacher, S.L., and Conboy, J.G. (2011) Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. Developmental Biology. 359(2):251-61
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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