Gene
tmem163b
- ID
- ZDB-GENE-091204-410
- Name
- transmembrane protein 163b
- Symbol
- tmem163b Nomenclature History
- Previous Names
-
- si:ch73-125n14.1
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable zinc ion binding activity. Acts upstream of or within myelination and oligodendrocyte development. Predicted to be located in bounding membrane of organelle; plasma membrane; and synapse. Predicted to be active in synaptic vesicle membrane. Is expressed in brain; central nervous system; spinal cord; and tail bud. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 25. Orthologous to human TMEM163 (transmembrane protein 163).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Yan et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-tmem163b | Yan et al., 2022 | |
CRISPR2-tmem163b | Yan et al., 2022 | |
MO1-tmem163b | N/A | Yan et al., 2022 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
hypomyelinating leukodystrophy 25 | Alliance | Leukodystrophy, hypomyelinating, 25 | 620243 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Cation efflux protein | Cation efflux transmembrane domain superfamily | Transmembrane protein 163 |
---|---|---|---|---|---|
UniProtKB:A0A0R4IQD0 | InterPro | 283 | |||
UniProtKB:F2Z4R5 | InterPro | 284 | |||
UniProtKB:A0AB13ABN3 | InterPro | 284 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
tmem163b-201
(1)
|
Ensembl | 891 nt | ||
mRNA |
tmem163b-202
(1)
|
Ensembl | 1,328 nt | ||
mRNA |
tmem163b-203
(1)
|
Ensembl | 1,747 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-125N14 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001423848 (1) | |||
Genomic | GenBank:CU571316 (1) | 125605 nt | ||
Polypeptide | UniProtKB:A0AB13ABN3 (1) | 284 aa |
- Yan, H., Yang, S., Hou, Y., Ali, S., Escobar, A., Gao, K., Duan, R., Kubisiak, T., Wang, J., Zhang, Y., Xiao, J., Jiang, Y., Zhang, T., Wu, Y., Burmeister, M., Wang, Q., Cuajungco, M.P., Wang, J. (2022) Functional Study of TMEM163 Gene Variants Associated with Hypomyelination Leukodystrophy. Cells. 11(8):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
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