Gene
vegfbb
- ID
- ZDB-GENE-091204-285
- Name
- vascular endothelial growth factor Bb
- Symbol
- vegfbb Nomenclature History
- Previous Names
-
- si:dkeyp-36h11.4
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable chemoattractant activity; growth factor activity; and vascular endothelial growth factor receptor binding activity. Predicted to be involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; positive regulation of chemotaxis; and sprouting angiogenesis. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in myocardial infarction and pulmonary hypertension. Orthologous to human VEGFB (vascular endothelial growth factor B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | PDGF/VEGF domain | Platelet-derived growth factor, conserved site | Platelet-derived/Vascular endothelial growth factor |
|---|---|---|---|---|---|---|
| UniProtKB:E9QDL3 | InterPro | 91 | ||||
| UniProtKB:A0A8M1RTE1 | InterPro | 152 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
vegfbb-201
(1)
|
Ensembl | 485 nt | ||
| mRNA |
vegfbb-202
(1)
|
Ensembl | 276 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-36H11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_003200871 (1) | |||
| Genomic | GenBank:CR631122 (1) | 80024 nt | ||
| Polypeptide | UniProtKB:A0A8M1RTE1 (1) | 152 aa |
- Fernezelian, D., Pfitsch, S., Rastegar, S., Diotel, N. (2024) Mapping the cellular expression patterns of vascular endothelial growth factor aa and bb genes and their receptors in the adult zebrafish brain during constitutive and regenerative neurogenesis. Neural Development. 19:1717
- Fernezelian, D., Rondeau, P., Gence, L., Diotel, N. (2024) Telencephalic stab wound injury induces regenerative angiogenesis and neurogenesis in zebrafish: unveiling the role of vascular endothelial growth factor signaling and microglia. Neural regeneration research. 20(10):2938-2954
- Mitra, S., Devi, S., Lee, M.S., Jui, J., Sahu, A., Goldman, D. (2022) Vegf signaling between Müller glia and vascular endothelial cells is regulated by immune cells and stimulates retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. 119:e2211690119e2211690119
- Lang, I., Virk, G., Zheng, D.C., Young, J., Nguyen, M.J., Amiri, R., Fong, M., Arata, A., Chadaideh, K.S., Walsh, S., Weiser, D.C. (2020) The Evolution of Duplicated Genes of the Cpi-17/Phi-1 (ppp1r14) Family of Protein Phosphatase 1 Inhibitors in Teleosts. International Journal of Molecular Sciences. 21(16):
- Jensen, L.D., Nakamura, M., Bräutigam, L., Li, X., Liu, Y., Samani, N.J., Cao, Y. (2015) VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 112(44):E5944-53
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